4854-47-1Relevant academic research and scientific papers
Synthesis of sterically hindered N-acylated amino acids from N-carboxyanhydrides
Schaefer, Gabriel,Bode, Jeffrey W.
supporting information, p. 1526 - 1529 (2014/04/03)
Sterically hindered N-acyl, gem-disubstituted amino acids are easily prepared via the addition of organometallic reagents to N-carboxyanhydrides (NCA). The process tolerates a wide variety of functional groups and allows the synthesis of amide products not readily accessible by traditional acylation chemistry. The existence of an isocyanate intermediate was established by in situ IR spectroscopy.
Straightforward, racemization-free synthesis of peptides with fairly to very bulky di- and trisubstituted glycines
Pinto, Filipa C.S.C.,Pereira-Lima, Sílvia M.M.A.,Maia, Hernani L.S.
scheme or table, p. 9165 - 9179 (2009/12/28)
Several fully protected tri- and pentapeptides containing a central symmetrical α,α-dialkyl glycine residue, with the alkyl group varying from methyl or ethyl to benzyl, were synthesized in good yields by a strategy based on the Ugi-Passerini reaction. Ea
