4877-23-0

Basic information

• Product Name: L-Serine, N-benzoyl-
• CAS NO: 4877-23-0
• Molecular Formula: C10H11NO4
• Molecular Weight: 209.202
• Mol File: 4877-23-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: L-Serine, N-benzoyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Serine, N-benzoyl-(4877-23-0)
• EPA Substance Registry System: L-Serine, N-benzoyl-(4877-23-0)

Safety Data

• Hazardous Substances Data: 4877-23-0(Hazardous Substances Data)

Upstream product

• 56-45-1 L-serin 
• 98-88-4 benzoyl chloride 
• 100-44-7 benzyl chloride 
• 138739-05-6 2-benzoylamino-3-hydroxypropionic acid benzyl ester 
• 65-85-0 benzoic acid 
• 10144-46-4 N-benzoyl-L-serine methyl ester 
• 50-00-0 formaldehyd 
• 1199-01-5 2-phenylazlactone 
• 302-84-1 serin 
• 1102900-87-7 N-(p-methylbenzoyl)-L-serine 
• 99-94-5 p-Toluic acid 
• 6756-74-7 S-benzoyl coenzyme A 
• 70326-37-3 phenyl(2-thioxothiazolidin-3-yl)methanone 
• 4582-71-2 benzoyl-DL-serine 

Downstream Products

• 99184-99-3 (4S)-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid 
• 10144-46-4 N-benzoyl-L-serine methyl ester 
• 24153-31-9 2-benzoylaminoacrylic acid methyl ester 
• 138739-05-6 2-benzoylamino-3-hydroxypropionic acid benzyl ester 
• 1522124-79-3 (S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide 
• 1522125-05-8 C₃₃H₃₆N₂O₁₀P₂*C₆H₁₅N 
• 1522124-83-9 (S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dihydrogen phosphate 
• 1522124-82-8 (S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dibenzyl phosphate 
• 75624-40-7 2-Phenyl-4,5-dihydro-oxazole-4-carboxylic acid benzyloxy-amide 
• 75624-39-4 1-(benzyloxy)-3-benzamido-2-azetidinone 
• 75624-34-9 O-benzyl-α-N-benzoyl-L-serine hydroxamate 

Relevant articles and documents

Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine

Three human G protein-coupled receptors (GPCRs)—GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3—are activated specifically by lysophosphatidylserine (LysoPS), an endogenous hydrolysis product of a cell membrane component, phosphatidylserine (PS). LysoPS consists of-serine, glycerol, and fatty acid moieties connected by phosphodiester and ester linkages. We previously generated potent and selective GPCR agonists by modification of the three modules and the ester linkage. Here, we show that a novel modification of the hydrophilic serine moiety, that is, N-acylations of the serine amine, converted a GPR174 agonist to potent GPR174 antagonists. Structural exploration of the amide functionality provided access to a range of activities from agonist to partial agonist to antagonist. The present study would provide a new strategy for the development of lysophospholipid receptor antagonists.

NEW DIFLUOROKETAMIDE DERIVATIVES AS HTRA1 INHIBITORS

The invention provides novel compounds having the general formula (I) wherein wherein R1, R2, R3, R4, R5, R6, R7, R3, R8, R9, R10, R11, R12 and R23 are as described herein, compositions including the compounds and methods of using the compounds.

Chemical pyrophosphorylation of functionally diverse peptides

A highly selective and convenient method for the synthesis of pyrophosphopeptides in solution is reported. The remarkable compatibility with functional groups (alcohol, thiol, amine, carboxylic acid) in the peptide substrates suggests that the intrinsic nucleophilicity of the phosphoserine residue is much higher than previously appreciated. Because the methodology operates in polar solvents, including water, a broad range of pyrophosphopeptides can be accessed. We envision these peptides will find widespread applications in the development of mass spectrometry and antibody-based detection methods for pyrophosphoproteins.