488151-84-4Relevant academic research and scientific papers
Enantioselective, iridium-catalyzed monoallylation of ammonia
Pouy, Mark J.,Stanley, Levi M.,Hartwig, John F.
supporting information; experimental part, p. 11312 - 11313 (2011/03/19)
(Chemical Equation Presented) Highly enantioselective, iridium-catalyzed monoallylations of ammonia are reported. These reactions occur with electron-neutral, -rich, and -poor cinnamyl carbonates, alkyl and trityloxy-substituted allylic carbonates, and di
A novel access to tetrahydro-β-carbolines via one-pot hydroformylation/fischer indole synthesis: Rearrangement of 3,3- spiroindoleninium cations
Bondzic, Bojan P.,Eilbracht, Peter
supporting information; experimental part, p. 3433 - 3436 (2009/05/07)
(Chemical Equation Presented) The two component one-pot hydroformylation/Fischer indole synthesis sequence of 2,5 dihydropyrroles and phenyl hydrazines allows a facile and convenient access to tetrahydro-β- carbolines in moderate to good yields.
Enantioselective synthesis of 2-substituted-N-Boc-Δ-4,5-piperidines
Agami, Claude,Couty, Francois,Evano, Gwilherm
, p. 4639 - 4643 (2007/10/03)
The title compounds were prepared through a synthetic sequence involving: (i) a reaction of the condensation product between an enantiopure β-amino alcohol and an aldehyde with allylmagnesium chloride; (ii) an N-allylation of the resulting secondary amine; (iii) a chemoselective cleavage of the β-amino alcohol residue; and (iv) a protection of the secondary amine followed by a ring closing metathesis. The advantageous use of (1R,2S)-norephedrine was demonstrated in these syntheses.
