18771-38-5Relevant articles and documents
Synthesis and antimicrobial evaluation of novel N-substituted 4-ethylsulfanyl-2-pyridones and triazolopyridines
Azzam, Rasha A.,Elgemeie, Galal H.
, p. 62 - 70 (2019)
The design and development of new methods for the synthesis of antimicrobial drugs is an important goal currently for medicinal chemistry. Sixteen novel N-substituted-amino-, N-arylsulfonylamino-, and N-aryl-4-ethylsulfanyl-2-pyridones were synthesized. A
Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors
Adhikari, Sharmila,Brownell, James E.,Calderwood, Emily F.,Chouitar, Jouhara,D'Amore, Natalie Roy,England, Dylan B.,Foley, Klaudia,Gould, Alexandra E.,Harrison, Sean J.,Huang, Shih-Chung,LeRoy, Patrick J.,Lok, David,Lublinsky, Anna,Ma, Li-Ting,Menon, Saurabh,Yang, Yu,Zhang, Ji
, (2020/08/13)
Autophagy is postulated to be required by cancer cells to survive periods of metabolic and/or hypoxic stress. ATG7 is the E1 enzyme that is required for activation of Ubl conjugation pathways involved in autophagosome formation. This article describes the design and optimization of pyrazolopyrimidine sulfamate compounds as potent and selective inhibitors of ATG7. Cellular levels of the autophagy markers, LC3B and NBR1, are regulated following treatment with these compounds.
An unprecedented trinuclear FeII triazole-based complex exhibiting a concerted and complete sharp spin transition above room temperature
Pittala, Narsimhulu,Thétiot, Franck,Charles, Catherine,Triki, Smail,Boukheddaden, Kamel,Chastanet, Guillaume,Marchivie, Mathieu
supporting information, p. 8356 - 8359 (2017/07/26)
We report a triazole-based trinuclear complex as the first example that displays a complete one-step first-order [HS-HS-HS] ? [LS-LS-LS] spin transition at 318 K. The strong ferro-elastic interactions, between the three metal centers, have been identified as the source of the concerted spin transition in this trinuclear complex.