488713-41-3Relevant articles and documents
Factor VIIa inhibitors: Gaining selectivity within the trypsin family
Shrader, William D.,Kolesnikov, Aleksandr,Burgess-Henry, Jana,Rai, Roopa,Hendrix, John,Hu, Huiyong,Torkelson, Steve,Ton, Tony,Young, Wendy B.,Katz, Bradley A.,Yu, Christine,Tang, Jie,Cabuslay, Ronnel,Sanford, Ellen,Janc, James W.,Sprengeler, Paul A.
, p. 1596 - 1600 (2007/10/03)
Within the trypsin family of coagulation proteases, obtaining highly selective inhibitors of factor VIIa has been challenging. We report a series of factor VIIa (fVIIa) inhibitors based on the 5-amidino-2-(2-hydroxy-biphenyl-3- yl)-benzimidazole (1) scaff