136705-25-4Relevant articles and documents
Small molecule inhibitors of plasma kallikrein
Young, Wendy B.,Rai, Roopa,Shrader, William D.,Burgess-Henry, Jana,Hu, Huiyong,Elrod, Kyle C.,Sprengeler, Paul A.,Katz, Bradley A.,Sukbuntherng, Juthamas,Mordenti, Joyce
, p. 2034 - 2036 (2006)
Plasma kallikrein is a serine protease that is involved in pathways of inflammation, complement fixation, coagulation, and fibrinolysis. Herein, we describe the SAR and structural binding modes of a series of inhibitors of plasma kallikrein as well as the
Factor VIIa inhibitors: Gaining selectivity within the trypsin family
Shrader, William D.,Kolesnikov, Aleksandr,Burgess-Henry, Jana,Rai, Roopa,Hendrix, John,Hu, Huiyong,Torkelson, Steve,Ton, Tony,Young, Wendy B.,Katz, Bradley A.,Yu, Christine,Tang, Jie,Cabuslay, Ronnel,Sanford, Ellen,Janc, James W.,Sprengeler, Paul A.
, p. 1596 - 1600 (2007/10/03)
Within the trypsin family of coagulation proteases, obtaining highly selective inhibitors of factor VIIa has been challenging. We report a series of factor VIIa (fVIIa) inhibitors based on the 5-amidino-2-(2-hydroxy-biphenyl-3- yl)-benzimidazole (1) scaff
Electrophilic Substitutions o η2-Coordinated Arenes: An Unprecedented Michael Addition for Phenol and Aniline
Kopach, Michael E.,Gonzalez, Javier,Harman, W. Dean
, p. 8972 - 8973 (2007/10/02)
-