4916-14-7

Basic information

• Product Name: methyl N-(phenyl)aziridine-2-carboxylate
• Synonyms: methyl N-(phenyl)aziridine-2-carboxylate
• CAS NO: 4916-14-7
• Molecular Weight: 177.203
• Mol File: 4916-14-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: methyl N-(phenyl)aziridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-(phenyl)aziridine-2-carboxylate(4916-14-7)
• EPA Substance Registry System: methyl N-(phenyl)aziridine-2-carboxylate(4916-14-7)

Safety Data

• Hazardous Substances Data: 4916-14-7(Hazardous Substances Data)

Upstream product

• 111750-22-2 N-phenyl-N-hydroxy-2,2-dimethylpropanamide 
• 292638-85-8 acrylic acid methyl ester 
• 67-56-1 methanol 
• 100-65-2 N-Phenylhydroxylamine 
• 186581-53-3 diazomethane 
• 4916-27-2 (+/-)-1-phenylaziridine-2-carbonitrile 
• 4916-14-7 methyl N-(phenyl)aziridine-2-carboxylate 
• 109-88-6 magnesium methanolate 
• 446242-99-5 ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-((S)-1-phenyl-aziridin-2-yl)-methanone 
• 1428345-82-7 (Z)-methyl 2-bromo-3-(phenylamino)acrylate 
• 1428346-14-8 methyl 2-bromo-3-(phenylamino)propanoate 
• 62-53-3 aniline 
• 586-96-9 Nitrosobenzene 
• 622-37-7 Phenyl azide 

Downstream Products

• 4916-14-7 methyl (S)-1-phenylaziridine-2-carboxylate 
• 446242-92-8 methyl (R)-(+)-1-phenylaziridine-2-carboxylate 
• 152494-07-0 S-1-phenylaziridine-2-carboxylic acid 
• 152494-07-0 R-1-phenylaziridine-2-carboxylic acid 
• 1010707-12-6 methyl 6-chloro-4-phenyl-1-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-2-carboxylate 
• 1010707-14-8 C₁₉H₁₈BrF₃N₂O₃ 
• 1010707-15-9 C₁₉H₁₈BrF₃N₂O₃ 
• 1010707-13-7 N-[2-(anilinomethyl)phenyl]trifluoroacetamide 
• 1010707-03-5 methyl 4-phenyl-1-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-2-carboxylate 
• 1010707-11-5 methyl 7-methyl-4-phenyl-1-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-2-carboxylate 
• 1010707-09-1 methyl 8-chloro-4-phenyl-1-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-2-carboxylate 
• 1010707-10-4 methyl 7-chloro-4-phenyl-1-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-2-carboxylate 

Relevant articles and documents

Palladium-catalyzed intermolecular dehydrogenative aminohalogenation of alkenes under molecular oxygen: An approach to brominated enamines

A novel and efficient palladium-catalyzed dehydrogenative aminohalogenation of alkenes with molecular oxygen as the sole oxidant has been developed. This protocol provides a valuable synthetic tool for the assembly of a wide range of brominated enamines under mild conditions, with unprecedented stereoselectivity and exceptional functional group tolerance. This attractive route for the synthesis of brominated enamines is of great significance due to the products' versatile reactivity for further transformations.

N-heterocyclic carbene (NHC)-catalyzed direct amidation of aldehydes with nitroso compounds

(Chemical Equation Presented) NHC-catalyzed direct amidation of aldehydes with nitroso compounds is a powerful method for the synthesis of N-arylhydroxamic acids. A variety of aryl, alkyl, alkenyl, and heterocyclic aldehydes were found to give excellent yields of the corresponding N-arylhydroxamic acids. This chemistry was also extended to the synthesis of chiral N-arylhydroxamic acids by kinetic resolution of α-branched aldehydes, a domino amidation-redox amination reaction of acrolein, and a three-component reaction for the synthesis of N-arylaziridines.

Enzymatic resolution of N-arylaziridine carboxylates

N-Arylaziridine-2-carboxylates have been enzymatically resolved using the lipase from Candida rugosa to afford optically active aziridine carboxylates in moderate to high enantiomeric purity. The absolute configuration of the unknown aziridine carboxylates was assigned as S by chemical correlation.