4917-29-7Relevant articles and documents
Mapping the active site in a chemzyme: Diversity in the N-substituent in the catalytic asymmetric aziridination of imines
Zhang, Yu,Lu, Zhenjie,Desai, Aman,Wulff, William D.
supporting information; experimental part, p. 5429 - 5432 (2009/06/20)
(Chemical Equation Presented) The active site of the aziridination catalyst derived from either the VANOL or VAPOL ligand and B(OPh)3 is larger than expected and can accommodate not only significant substitution on the diarylmethyl unit of the imine but also that alkyl (but not perfluorylalkyl) substituents on the aryl groups lead to enhanced rates and enantioselection. The screen of diarylmethyl N-substituents on the imine revealed that the 3,5-di-tert-butyldianisylmethyl group (BUDAM) gave exceptionally high asymmetric inductions for imines of aryl aldehydes.
Anodic Cyanation of tert-Butylated Anisoles: Competitive Aromatic Additions and Substitutions
Yoshida, Kunihisa,Takeda, Kazusada,Fueno, Takayuki
, p. 3095 - 3098 (2007/10/02)
The electrooxidation of sevral tert-butylated anisoles has been carried out in ,ethanol containing sodium cyanide at a Pt anode in a divided cell.Two types of reactions occured competitively, aromatic-ring addition and substitution.Increasing the level of tert-butyl substitution raises the relative extent of addition to the aromatic ring.An MO calculation has indicated that the order of orientational preference for substitution of the aromatic hydrogen of alkylanisole cation radicals is explained in terms of the LUMO electron densities calculated for the cation radicals.The effect of structure on the oxidation potential of alkylanisoles has also been studied. para Substitution lowers the oxidation potential while ortho substitution raises the potential.