4917-29-7

Upstream product

• 1516-95-6 2,6-di-tert-butyl-anisole 
• 143-33-9 sodium cyanide 
• 1988-88-1 2,6-di-tert-butyl-4-cyanophenol 
• 74-88-4 methyl iodide 
• 1516-96-7 4-bromo-2,6-di-tert-butylanisole 
• 544-92-3 copper(I) cyanide 
• 67-56-1 methanol 

Downstream Products

• 1057337-56-0 3,5-di-tert-butyl-4-methoxybenzenecarboximidamide 
• 1372810-27-9 3-(3,5-di(tertbutyl)-4-methoxyphenyl)-8-(diethylamino)-[1,2,4]triazolo[4,3-a]pyrazine-5,6-dicarbonitrile 
• 1372810-18-8 5-(3,5-di(tertbutyl)-4-methoxyphenyl)-1H-tetrazole 
• 94430-24-7 3,5-Bis(1,1-dimethylethyl)-4-(methoxy)-benzamide 
• 148773-28-8 5-<3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl>-1,3,4-thiazole-2(3H)-thione 
• 130116-26-6 2,6-Di-tert-butyl-4-(5-methylsulfanyl-[1,3,4]thiadiazol-2-yl)-phenol 
• 130116-03-9 Cl-986 
• 148773-27-7 3,5-bis(1,1-dimethylethyl)-4-methoxybenzenecarboximidic acid hydrazide 

Relevant academic research and scientific papers

Mapping the active site in a chemzyme: Diversity in the N-substituent in the catalytic asymmetric aziridination of imines

(Chemical Equation Presented) The active site of the aziridination catalyst derived from either the VANOL or VAPOL ligand and B(OPh)3 is larger than expected and can accommodate not only significant substitution on the diarylmethyl unit of the imine but also that alkyl (but not perfluorylalkyl) substituents on the aryl groups lead to enhanced rates and enantioselection. The screen of diarylmethyl N-substituents on the imine revealed that the 3,5-di-tert-butyldianisylmethyl group (BUDAM) gave exceptionally high asymmetric inductions for imines of aryl aldehydes.

2-ARYLTHIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS

The invention encompasses compounds of Formula I or pharmaceutically acceptable salts thereof, which are modulators of the CXCR3 chemokine receptor function useful for the treatment or prevention of pathogenic inflammatory processes, autoimmune diseases or graft rejection processes. Methods of use and pharmaceutical compositions are also encompassed.

Anodic Cyanation of tert-Butylated Anisoles: Competitive Aromatic Additions and Substitutions

The electrooxidation of sevral tert-butylated anisoles has been carried out in ,ethanol containing sodium cyanide at a Pt anode in a divided cell.Two types of reactions occured competitively, aromatic-ring addition and substitution.Increasing the level of tert-butyl substitution raises the relative extent of addition to the aromatic ring.An MO calculation has indicated that the order of orientational preference for substitution of the aromatic hydrogen of alkylanisole cation radicals is explained in terms of the LUMO electron densities calculated for the cation radicals.The effect of structure on the oxidation potential of alkylanisoles has also been studied. para Substitution lowers the oxidation potential while ortho substitution raises the potential.