Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase

DOI: 10.1016/j.bmcl.2006.12.086

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1679 - 1683 (2007)

Update date:2022-07-30

Topics:

Authors:

Cheney, I. Wayne

Yan, Shunqi

Appleby, Todd

Walker, Heli

Vo, Todd

Yao, Nanhua

Hamatake, Robert

Hong, Zhi

Wu, Jim Z.

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Article abstract of DOI:10.1016/j.bmcl.2006.12.086

A novel series of highly potent substituted pyridone Pim-1 kinase inhibitors is described. Structural requirements for in vitro activity are outlined as well as a complex crystal structure with the most potent Pim-1 inhibitor reported (IC₅₀ = 5

Full text of DOI:10.1016/j.bmcl.2006.12.086

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