4920-36-9

Usage

Uses

Used in Pharmaceutical Industry:
2,3,6-trifluoro-4-methoxybenzene is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3,6-trifluoro-4-methoxybenzene serves as a key intermediate for the production of pesticides and other agrochemicals. Its incorporation enhances the effectiveness and selectivity of these compounds in agricultural applications.
Used in Organic Compounds Synthesis:
2,3,6-trifluoro-4-methoxybenzene is employed as a building block in the synthesis of a wide range of organic compounds. Its presence in these molecules can impart desirable characteristics, such as increased stability or reactivity, depending on the specific application.
Used in Specialty Chemicals and Materials Production:
2,3,6-trifluoro-4-methoxybenzene is also used in the production of specialty chemicals and materials, where its unique properties can be leveraged to create high-performance products for various applications across different industries.

Upstream product

• 67-56-1 methanol 
• 2367-82-0 1,2,3,5-tetrafluorobenzene 
• 124-41-4 sodium methylate 

Relevant academic research and scientific papers

REACTIONS OF AROMATIC COMPOUNDS WITH NUCLEOPHILIC REAGENTS IN LIQUID AMMONIA. REACTION OF POLYFLUORINATED DERIVATIVES OF BENZENE WITH SODIUM AMIDE

Under the influence of sodium amide in liquid ammonia at a temperature no higher than -33 deg C pentafluorobenzene, 1,2,4,5-tetrafluorobenzene, and 1,3-difluorobenzene undergo deprotonation with the formation of fluorinated phenyl anions, which are resistant to the elimination of a fluoride ion and can be detected by the formation of the products from interaction with electrophiles (with the initial compound in the first case and with methyl iodide in the other two cases). 1,3,5-Trifluorobenzene behaves similarly in reaction with one equivalent of sodium amide, but with two equivalents of sodium amide this compound and 1,2,3,5-tetrafluorob enzene undergo substitution of a fluorine atom by an amino group with the formation of 3,5-di- and 3,4,5-trifluoroanilines respectively.This is clearly due to the double deprotonation of these compounds with the formation of polyfluorinated m-phenylene dianions, which are then converted with the elimination of a fluoride ion into the corresponding dehydrophenyl anions.

Mechanisms for Reactions of Halogenated Compounds. Part 3. Variation in Activating Influence of Halogen Substituents in Nucleophilic Aromatic Substitution

Rate constants are reported for reactions of polyhalogeno-pyridines and -benzenes with sodium methoxide in methanol.Relative activating effects of individual fluorine and chlorine atoms at positions ortho, meta, and para to the reaction site are determined and compared with orders determined from reactions involving ammonia in aqueous dioxan.The results are remarkably similar.Additional support is provided for earlier explanations of the activating effects of ortho-fluorine and -chlorine.Activation parameters, determined for reactions of polyhalogenepyridines with ammonia in aqueous dioxan, clearly demonstrate that differences in reactivity along the series arise mainly from changes in activation energy.