4923-12-0

Basic information

• Product Name: 2-(pyridin-2-ylcarbonyl)hydrazinecarbothioamide
• CAS NO: 4923-12-0
• Molecular Formula: C₇H₈N₄OS
• Molecular Weight: 196.2296
• Mol File: 4923-12-0.mol
• Article Data: 5

Chemical Properties

• Density: 1.396g/cm³
• Refractive Index: 1.668
• CAS DataBase Reference: 2-(pyridin-2-ylcarbonyl)hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(pyridin-2-ylcarbonyl)hydrazinecarbothioamide(4923-12-0)
• EPA Substance Registry System: 2-(pyridin-2-ylcarbonyl)hydrazinecarbothioamide(4923-12-0)

Safety Data

• Hazardous Substances Data: 4923-12-0(Hazardous Substances Data)

Usage

General Description

2-(pyridin-2-ylcarbonyl)hydrazinecarbothioamide, also known as isoniazid, is a synthetic organic compound with the chemical formula C6H7N3O. It is a hydrazide derivative and is commonly used as an antibiotic medication to treat tuberculosis. Isoniazid works by inhibiting the synthesis of mycolic acid, a key component of the bacterial cell wall, and is considered a first-line treatment for active tuberculosis. In addition to its antibacterial properties, isoniazid also exhibits antifungal and antituberculotic activity. However, it is essential to be cautious when using isoniazid, as it can cause liver damage and other adverse effects in some individuals.

Upstream product

• 84555-18-0 cyanomethyl 2-pyridinecarboxylate 
• 79-19-6 thiosemicarbazide 
• 39901-94-5 2-picolinoyl chloride hydrochloride 
• 1452-63-7 picolinic acid hydrazide 
• 333-20-0 potassium thioacyanate 
• 2459-07-6 methyl pyridine-2-carboxylate 
• 98-98-6 2-Picolinic acid 

Downstream Products

• 32362-89-3 5-(pyridin-2-yl)-4H-1,2,4-triazole-3-thiol 
• 5711-72-8 2-amino-5-(pyridin-2-yl)-1,3,4-oxadiazole 

Relevant articles and documents

Synthesis, structural characterization and thermal properties of three copper(II) complexes based on aryl hydrazide ligands

The thiosemicarbazide and hydrazide Cu(II) complexes, [Cu3L 21(py)4Cl2] (1), [Cu(HL 2)py] (2) and [Cu(HL3)py] (3), (H2L1 = 1-picolinoylthiosemicarbazide, H

N-Heterocyclic dicarboxylic acids: Broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria

In an effort to identify novel, broad-spectrum inhibitors against the metallo-β-lactamases (MβLs), several N-heterocyclic derivatives were tested as inhibitors of MβLs CcrA, ImiS, and L1, which are representative enzymes from the distinct MβL subclasses. Three N-heterocyclic dicarboxylic acid derivatives were competitive inhibitors of CcrA and L1, exhibiting K i values ≤2 μM, while only 2,4-thiazolidinedicarboxylic acid (1b) was a competitive inhibitor of ImiS. Two 2-mercapto-1,3,4-thiadiazole derivatives were noncompetitive inhibitors of CcrA and ImiS, exhibiting K i values 7 μM; however, these same compounds did not inhibit L1. Two 2-mercapto-1,3,4-triazole derivatives were shown not to inhibit any of the tested MβLs. The N-heterocyclic derivatives were tested for antibacterial activity by examining the MIC values for existing antibiotics in the presence/absence of these derivatives. Consistent with the steady-state inhibition data, the inclusion of three N-heterocyclic dicarboxylic acid derivatives resulted in lower MIC values when using Escherichia coli BL21(DE3) cells containing the CcrA or L1 plasmids or Klebsiella pneumoniae (ATCC 700603), while 1b was the only dicarboxylic acid derivative to lower the MIC value of E. coli cells containing the ImiS plasmid. Inclusion of the 2-mercapto-1,3,4- thiadiazole derivatives resulted in lower MIC values for E. coli cells containing ImiS or L1 plasmids; however, these derivatives did not alter the MIC values for K. pneumoniae or E. coli cells containing the L1 plasmid. None of the N-heterocyclic derivatives affected the MIC of two methicillin resistant Staphylococcus aureus (MRSA) strains. Taken together, these studies demonstrate that N-heterocyclic dicarboxylic acids 1a-c and pyridylmercaptothiadiazoles 2a,b are good scaffolds for future broad-spectrum inhibitors of the MβLs.

Substituted s-triazoles and related compounds.

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