493012-77-4

Upstream product

• 4163-65-9 per-O-acetyl-α-D-mannopyranose 
• 363619-62-9 C₄₈H₅₁O₁₈P 
• 363619-57-2 6-O-acetyl-2,3,4-tri-O-benzoyl-α-D-galactopyranosyl trichloroacetimidate 
• 363619-58-3 C₃₀H₃₁O₁₁P 
• 363619-55-0 C₃₁H₂₈O₁₁ 
• 363619-56-1 C₂₉H₂₅BrO₉ 
• 363619-54-9 ((3aS,4S,6R,7R,7aS)-7-Benzyloxy-6-benzyloxymethyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethyl)-phosphonic acid dimethyl ester 
• 363619-59-4 Benzoic acid (3aS,4S,6R,7R,7aS)-4-(dimethoxy-phosphorylmethyl)-7-hydroxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-ylmethyl ester 
• 170998-34-2 Allyl 4,6-di-O-benzyl-2,3-O-isopropylidene-α-D-mannopyranoside 
• 119111-31-8 allyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 
• 61277-56-3 1,6-di-O-acetyl-2,3,4-tri-O-benzyl-α/β-D-galactopyranose 
• 85207-15-4 allyl 2,3:4,6-di-O-isopropylidene-α-D-mannopyranoside 
• 98-88-4 benzoyl chloride 
• 41308-76-3 allyl α-D-mannopyranoside 

Relevant academic research and scientific papers

Synthesis of oligomeric phosphono analogues of Leishmania lipophosphoglycan fragments

A set of isosteric phosphono (C-glycoside) analogues of Leishmania lipophosphoglycan fragments have been synthesised by making use of a sequence of uniformly stereoselective glycosylation reactions of phosphono-oligosaccharide glycosyl acceptors with phosphono-oligosaccharide thioglycosides.

Synthesis of β-D-Galp-(1 →4)-α-D-Manp methanephosphonate, a substrate analogue for the elongating α-D-mannosyl phosphate transferase in the Leishmania

An isosteric C-glycoside phosphono analogue of dec-9-enyl β-D-galactopyranosyl-(1 →4)-α-D-mannopyranosyl phosphate was synthesised and showed high biological activity in the Leishmania MPT assay. A one-step Horner-Emmons/Michael reaction was developed for the stereoselective preparation of α-D-mannosyl methanephosphonate derivatives.