493040-20-3

Basic information

• Product Name: 1-benzyl-4-methylpiperidin-3-ol 4-methylbenzenesulfonate
• Synonyms: 1-benzyl-4-methylpiperidin-3-ol 4-methylbenzenesulfonate;1-benzyl-4-methylpiperidin-3-ol 4-methylbenzenesulfote
• CAS NO: 493040-20-3
• Molecular Weight: 0
• Mol File: 493040-20-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-benzyl-4-methylpiperidin-3-ol 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-methylpiperidin-3-ol 4-methylbenzenesulfonate(493040-20-3)
• EPA Substance Registry System: 1-benzyl-4-methylpiperidin-3-ol 4-methylbenzenesulfonate(493040-20-3)

Safety Data

• Hazardous Substances Data: 493040-20-3(Hazardous Substances Data)

Usage

Uses

1-Benzyl-4-methylpiperidin-3-ol 4-Methylbenzenesulfonate is used in organic synthesis.

Upstream product

• 32018-56-7 1-benzyl-4-methyl-1 ,2,3,6-tetrahydropyridine 
• 104-15-4 toluene-4-sulfonic acid 
• 23662-66-0 1-benzyl-4-methylpyridinium chloride 
• 108-89-4 picoline 
• 100-44-7 benzyl chloride 

Downstream Products

• 32018-96-5 1-benzyl-4-methyl-piperidin-3-one 

Relevant articles and documents

Development of a scaleable route for the production of cis-N-benzyl-3-methylamino-4-methylpiperidine

The synthesis of cis-N-benzyl-3-methylamino-4-methylpiperidine (5) via hydroboration of tetrahydropyridine 3 followed by oxidation and reductive amination was optimized and scaled up to produce 10-kg quantities of product. Three routes to 3 were identified, and the reduction of pyridinium salt 7 was selected as the most preferable to run on-scale. The hydroboration and oxidative workup were carefully studied to optimize throughput on that transformation, as was the reductive amination.