87967-38-2Relevant articles and documents
Copper-catalyzed: N -(hetero)arylation of amino acids in water
Sharma, Krishna K.,Mandloi, Meenakshi,Rai, Neha,Jain, Rahul
, p. 96762 - 96767 (2016/10/24)
An environmentally benign, mild, cost-effective and gram-scalable copper-catalyzed method for the N-(hetero)arylation of zwitterionic natural and unnatural amino acids using 2-isobutyrylcyclohexanone as a β-diketone ligand and aryl bromides as coupling partners in water for 50 min at 90 °C under microwave irradiation is reported. Electronically and sterically diverse aryl coupling partners were inserted efficiently, including challenging heteroaryl electrophilic partners in high yields without affecting the enantiopurity of the product.
A cyclohexanecarboxamide derivative with inhibitory effects on Schistosoma mansoni cercarial serine protease and penetration of mice skin by the parasite
Bahgat, Mahmoud,Aboul-Enein, Mohamed N.,El Azzouny, Aida A.,Maghraby, Amany,Ruppel, Andreas,Soliman, Wael M.
scheme or table, p. 333 - 340 (2009/12/24)
A cyclohexanecarboxamide derivative, N-phenyl-N-[1-(piperidine-1-carbonyl) cyclohexyl] benzamide (MNRC-5), was evaluated for its inhibitory effects on Schistosoma mansoni cercarial serine protease activity and cercarial penetration. MNRC-5 exerted an inhi
4-Aminophenoxyacetic acids as a novel class of reversible cathepsin K inhibitors
Shinozuka, Tsuyoshi,Shimada, Kousei,Matsui, Satoshi,Yamane, Takahiro,Ama, Mayumi,Fukuda, Takeshi,Taki, Motohiko,Naito, Satoru
, p. 1502 - 1505 (2007/10/03)
We have designed and synthesized a novel series of 3-biphenylamino acid amides as cathepsin K inhibitors based on compound I. In these inhibitors, we have discovered 4-aminophenoxyacetic acids 43 and 47 with good IC50 values, although lipophili
