495-08-9

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 97, p. 5272, 1975 DOI: 10.1021/ja00851a042

Purification Methods

Crystallise the alcohol from ligroin, CHCl3, AcOH or H2O. Sublime it at ~70o under high vacuum. [Beilstein 6 II 1084, 6 III 6326.]

InChI:InChI=1/C7H8O3/c8-4-5-3-6(9)1-2-7(5)10/h1-3,8-10H,4H2

Upstream product

• 1194-98-5 2,5-Dihydroxybenzaldehyde 
• 123-31-9 hydroquinone 
• 644-17-7 2-hydroxymethyl-1,4-benzoquinone 
• 1250873-75-6 4-hydroxy-6-methylene-2,4-cyclohexadien-1-one 
• 1250873-77-8 2-(ethoxymethyl)benzene-1,4-diol 
• 1250873-78-9 (2,5-dihydroxy-1-phenyl)methyltrimethylammonium iodide 
• 1447933-44-9 2-(2-bromomethyl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 27060-75-9 4-bromo-3-methylanisole 
• 41951-76-2 2-hydroxy-5-methoxybenzyl alcohol 
• 50-00-0 formaldehyd 
• 150-76-5 4-methoxy-phenol 
• 33524-31-1 2,5-dimethoxybenzyl alcohol 

Downstream Products

• 33524-31-1 2,5-dimethoxybenzyl alcohol 
• 644-17-7 2-hydroxymethyl-1,4-benzoquinone 
• 95-71-6 2-methylbenzene-1,4-diol 
• 6616-58-6 1,4-diacetoxy-2-acetoxymethyl-benzene 
• 1194-98-5 2,5-Dihydroxybenzaldehyde 
• 1250873-77-8 2-(ethoxymethyl)benzene-1,4-diol 
• 1250873-75-6 4-hydroxy-6-methylene-2,4-cyclohexadien-1-one 
• 553-97-9 2-Methyl-1,4-benzoquinone 
• 114480-36-3 2,5-bis(4-n-butoxybenzoyloxy)benzyl alcohol 
• 114480-35-2 2,5-bis(4-ethoxybenzoyloxy)benzyl alcohol 
• 105252-91-3 2,5-bis[(4'-(methoxy)benzoyl)oxy]benzyl alcohol 

Relevant academic research and scientific papers

A supple red alkone epirubicin than star-intermediates of the synthesis method (by machine translation)

The invention belongs to the field of medical synthesis, in particular relates to a supple red alkone epirubicin than star intermediate chemical synthesis method. The invention relates to 2, 5 - dihydroxy benzyl alcohol as the raw material synthetic suppl

Daunomycinone intermediate compound

The invention belongs to the field of medicine synthesis and particularly provides a daunomycinone intermediate compound. Daunomycinone can be purely chemically synthesized by adoption of the intermediate compound. By adoption of 2,5-dyhydroxylbenzyl alco

Daunomycinone intermediate compound

The invention belongs to the field of medicine synthesis and particularly provides a daunomycinone intermediate compound. Daunomycinone can be purely chemically synthesized by adoption of the intermediate compound. By adoption of 2,5-dyhydroxylbenzyl alco

Daunomycinone intermediate compound

The invention belongs to the field of medicine synthesis and particularly provides a daunomycinone intermediate compound. By adoption of 2,5-dyhydroxylbenzyl alcohol as a raw material for daunomycinone synthesis, low cost of raw materials, mild reaction c

Daunomycinone intermediate compound

The invention belongs to the field of medicine synthesis and particularly provides a daunomycinone intermediate compound. Daunomycinone can be purely chemically synthesized by adoption of the intermediate compound. By adoption of 2,5-dyhydroxylbenzyl alco

Daunomycinone intermediate compound

The invention belongs to the field of medicine synthesis and particularly provides a daunomycinone intermediate compound. Daunomycinone can be purely chemically synthesized by adoption of the intermediate compound. By adoption of 2,5-dyhydroxylbenzyl alco

Daunomycinone intermediate compound

The invention belongs to the field of medicine synthesis and particularly provides a daunomycinone intermediate compound. Daunomycinone can be purely chemically synthesized by adoption of the intermediate compound. By adoption of 2,5-dyhydroxylbenzyl alco

Regioselective synthesis of gentisyl alcohol-type marine natural products

Gentisyl alcohol-type natural products, possessing various important biological properties, have been synthesized from 4-methoxyphenol by using a selective phenol monohydroxymethylation/monochlorination, a CAN oxidation and a sodium dithionite reduction as the key steps. The natural product synthesis is efficient, atom- and step-economical, and requires no protecting groups.

Lewis Base Catalyzed Intramolecular Reduction of Salicylaldehydes by Pinacol-Derived Chlorohydrosilane

A newly developed stable chlorohydrosilane derived from pinacol is herein described. This was successfully used in the reduction of salicylaldehydes in reasonable to excellent yields (51–97 %). The ability of the hydrosilane to react as a reducing agent is increased upon the in situ formation of a trialkoxyhydrosilane and activation with a Lewis base, as further indicated by density functional theory studies. 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) was identified to be a suitable catalyst for this metal-free reduction, promoting the regio- and chemoselective reduction of aldehydes in ortho-position to phenols, despite the presence of vicinal ketones. The performance of pinacol-derived chlorohydrosilane in the reduction of salicylaldehydes was further observed to be superior to that of well-established commercially available chlorohydrosilanes.

Synthesis of 2,5-(4-alkoxybenzoyloxy)benzyl acrylates and cinnamates, monomers for side chain liquid crystal polymers

Abstract: A variety of 2,5-(4-alkoxybenzoyloxy)benzyl acrylates and cinnamates, which can serve as monomers for side chain liquid crystal polymers, were readily synthesized from hydroquinone. Instead of the rare and expensive 2,5-dihydroxybenzaldehyde, ch