41951-76-2

Basic information

• Product Name: 2-HYDROXY-5-METHOXYBENZYL ALCOHOL
• Synonyms: RARECHEM AL BD 0042;2-HYDROXY-5-METHOXYBENZYL ALCOHOL;2-HYDROXYMETHYL-4-METHOXY-PHENOL;2-hydroxy-5-methoxyBenzenemethanol;2-HYDROXY-5-METHOXYBENZYL ALCOHOL(WXC08345)
• CAS NO: 41951-76-2
• Molecular Formula: C₈H₁₀O₃
• Molecular Weight: 154.16
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 41951-76-2.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 265.4°C at 760 mmHg
• Flash Point: 114.3°C
• Appearance: /
• Density: 1.226g/cm³
• Vapor Pressure: 0.00559mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 2-HYDROXY-5-METHOXYBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-5-METHOXYBENZYL ALCOHOL(41951-76-2)
• EPA Substance Registry System: 2-HYDROXY-5-METHOXYBENZYL ALCOHOL(41951-76-2)

Safety Data

• Hazardous Substances Data: 41951-76-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H10O3/c1-11-7-2-3-8(10)6(4-7)5-9/h2-4,9-10H,5H2,1H3

Upstream product

• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 50-00-0 formaldehyd 
• 150-76-5 4-methoxy-phenol 
• 23562-84-7 4-methoxy-2-(morpholino-N-methyl)phenol 
• 123-31-9 hydroquinone 
• 27060-75-9 4-bromo-3-methylanisole 
• 1447933-44-9 2-(2-bromomethyl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 1250873-79-0 2-(ethoxymethyl)-4-methoxyphenol 
• 64-19-7 acetic acid 
• 908005-01-6 4-methoxy-6-methylene-2,4-cyclohexadien-1-one 
• 201165-98-2 4-Hydroxy-1-[(2R,5S)-5-(6-methoxy-2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-2,5-dihydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one 
• 195885-81-5 1-[(2R,4S,5S)-4-Azido-5-(6-methoxy-2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 195971-19-8 5-Fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(6-methoxy-2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione 
• 201165-98-2 1-[(2R,5S)-5-(6-Methoxy-2-oxo-4H-2λ⁵-benzo[1,3,2]dioxaphosphinin-2-yloxymethyl)-2,5-dihydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 600708-77-8 [2-(2,2-dimethoxy-ethoxy)-5-methoxy-phenyl]-methanol 
• 736986-01-9 6-methoxy-2-methyl-4H-benzo[1,3]dioxane 
• 817631-20-2 [2-(methoxyethoxymethoxymethyl)]-4-methoxyphenol 
• 91497-79-9 1-acetoxy-2-acetoxymethyl-4-methoxybenzene 
• 1250873-79-0 2-(ethoxymethyl)-4-methoxyphenol 
• 908005-01-6 4-methoxy-6-methylene-2,4-cyclohexadien-1-one 
• 736985-90-3 2-ethoxy-6-methoxychroman 
• 495-08-9 gentisyl alcohol 
• 95-71-6 2-methylbenzene-1,4-diol 
• 553-97-9 2-Methyl-1,4-benzoquinone 
• 5307-05-1 1-hydroxy-4-methoxy-2-methylbenzene 
• 60530-20-3 2-<(phenylthio)methyl>-4-methoxyphenol 
• 95332-12-0 6-methoxy-3-(4-methoxyphenyl)-2H-chromene 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 

Relevant articles and documents

Regioselective synthesis of gentisyl alcohol-type marine natural products

Gentisyl alcohol-type natural products, possessing various important biological properties, have been synthesized from 4-methoxyphenol by using a selective phenol monohydroxymethylation/monochlorination, a CAN oxidation and a sodium dithionite reduction as the key steps. The natural product synthesis is efficient, atom- and step-economical, and requires no protecting groups.

Preparation method of sateripol compounds

The invention relates to a preparation method of sateripol compounds, and belongs to the field of chemical synthesis. 4-alkoxy saligenol compounds are prepared by carrying out a reaction of 4-alkoxy phenol compounds and aldehyde ketone compounds, the gent

MAO Inhibitory Activity of 2-Arylbenzofurans versus 3-Arylcoumarins: Synthesis, invitro Study, and Docking Calculations

Monoamine oxidase (MAO) is an important drug target for the treatment of neurological disorders. Several 3-arylcoumarin derivatives were previously described as interesting selective MAO-B inhibitors. Preserving the trans-stilbene structure, a series of 2-arylbenzofuran and corresponding 3-arylcoumarin derivatives were synthesized and evaluated as inhibitors of both MAO isoforms, MAO-A and MAO-B. In general, both types of derivatives were found to be selective MAO-B inhibitors, with IC50 values in the nano- to micromolar range. 5-Nitro-2-(4-methoxyphenyl)benzofuran (8) is the most active compound of the benzofuran series, presenting MAO-B selectivity and reversible inhibition (IC50=140nM). 3-(4′-Methoxyphenyl)-6-nitrocoumarin (15), with the same substitution pattern as that of compound 8, was found to be the most active MAO-B inhibitor of the coumarin series (IC50=3nM). However, 3-phenylcoumarin 14 showed activity in the same range (IC50=6nM), is reversible, and also severalfold more selective than compound 15. Docking experiments for the most active compounds into the MAO-B and MAO-A binding pockets highlighted different interactions between the derivative classes (2-arylbenzofurans and 3-arylcoumarins), and provided new information about the enzyme-inhibitor interaction and the potential therapeutic application of these scaffolds.