4957-24-8Relevant academic research and scientific papers
Chiral anion phase-transfer catalysis applied to the direct enantioselective fluorinative dearomatization of phenols
Phipps, Robert J.,Toste, F. Dean
supporting information, p. 1268 - 1271 (2013/03/14)
Chiral anion phase-transfer catalysis has enabled the direct and highly enantioselective fluorinative dearomatization of phenols catalyzed by a BINOL-derived phosphate. The process efficiently transforms simple, readily available phenols into fluorinated chiral small molecules bearing reactive functionality under ambient reaction conditions with high enantioselectivity. The close relationship of the products with well-studied o-quinols provides numerous avenues for synthetic elaboration and exciting opportunities for bioisosteric replacement of hydroxyl with fluorine in natural products.
HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS
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Page/Page column 35; 48, (2008/06/13)
A compound of formula (I): wherein either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy,-CN,-C(Rc)2OH,-N(Rd)C(=X)Rc,-C(=X)N(Rc)(Rd),-S(O)m-Rc,-N(Rc)(Rd)S(O)2,-S(O)2N(R c)(Rd),-N(Re)2, aryl optionally substituted with Ra or-O-aryl optionally substituted with Ra; or B is present and is-(CH2)n-,-C(Rb)2-or-O-, or B taken together with A or Z can be-C=C(Rb)-,-C(Rb)=C-,-CH2-CH(R b)-or-CH(Rb)-CH2-; D is-O-or-S(O) m,-; E is a bond or is-(CH2)n-,-N(R d)-,-(CH2)nN(Rd)-or-N(R d)(CH2)n-; F is-C(=X)-; G is-(CH2 )n-,-N(Rd)-,-(CH2)nN(R d)-or-N(Rd)(CH2)n; J is a bond,-O-,-N(RC)C(=X)-,-C(=X)N(Rc)-,-S(O)m,-,-N(Rc)S(O)m-,-S(O)nN(Rc)-,-N(Re)-or-N(Rg)(Rh); K is a bond, alkylene, cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene; and L is hydrogen or a terminal group; has therapeutic utility.
Indan-5-yl-N-methylcarbamic acid esters
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, (2008/06/13)
Indan-5-yl-N-methylcarbamic acid esters of the formula STR1 in which R represents hydrogen or C1 -C4 alkyl, R1 represents hydrogen or C1 -C4 alkyl, R2 represents C1 -C4 alkyl, R3 represents hydrogen or C1 -C4 alkyl and R4 represents hydrogen, chlorine, bromine, C1 -C4 alkyl or C1 -C4 alkoxy, Which possess arthropodicidal and fungicidal properties.
