49593-54-6

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 98-86-2 acetophenone 
• 57-13-6 urea 
• 22252-15-9 trans-4-methoxychalcone 
• 100-52-7 benzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 

Downstream Products

• 24030-09-9 6-(4-methoxyphenyl)-4-phenyl-2-oxo-1,2-dihydropyrimidine 

Relevant academic research and scientific papers

Synthesis and in vitro and in vivo antitumor/anticancer activity of novel O-Mannich bases of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-ones

A new series of [4,6 substituted diaryl-1,6-dihydropyrimidin-2-yl-oxymethyl]-amines 5a-o have been synthesized by the Mannich condensation on the respective 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-ones 4, in basic medium using formaldehyde along with three

PEG-SANM nanocomposite: A new catalytic application towards clean and highly efficient Biginelli-like reaction under solvent-free conditions

A series of pyrimidinone derivatives were efficiently synthesized using PEG-SANM nanocomposite as the solid acid nanocatalyst under mild and solvent-free conditions. The generality of the process was successfully demonstrated by variation of the starting

3,4-Hydropyrimidin-2-(1H)one derivatives: Solid silica-based sulfonic acid catalyzed microwave-assisted synthesis and their biological evaluation as antihypertensive and calcium channel blocking agents

Microwave assisted simple, efficient procedure for one-pot Biginelli condensation reaction of aldehydes, β-ketoesters, and urea or thiourea in solvent-free condition employing solid silica-based sulfonic acid as a novel, heterogeneous reusable catalyst is

A novel protocol for solvent-free synthesis of 4,6-diaryl-3,4- dihydropyrimidine-2(1H)-ones catalyzed by metal oxide-MWCNTs nanocomposites

A Biginelli-like condensation is described using acetophenone as active methylene compound with aldehydes and urea to furnish pyrimidinone analogues under solvent-free conditions. In this paper, besides the preparation of nanocomposites based on MWCNTs, o

MnO2-MWCNT nanocomposites as efficient catalyst in the synthesis of Biginelli-type compounds under microwave radiation

A novel Biginelli-like cyclocondensation reaction is efficiently catalyzed by MnO2-CNT nanocomposites as a new catalyst under microwave irradiation and solvent-free conditions in excellent yields. The major advantages of the present method are high yields, short reaction times and solvent-free reaction conditions, reducing reaction steps and purification of products by non-chromatographic methods. The activity, recovery and reusability of the catalyst are found to be good.

Facile Biginelli-type reactions catalysed by super acidic ionic liquid under solvent-free conditions

[MeC(OH)2]+ClO4-?as a super acidic ionic liquid is an extremely active catalyst for Biginelli-type reactions. The present method is especially effective for the inactive aliphatic aldehydes. The solvent-free conditions, high catalytic activity, wide substrates tolerance and convenient product isolation make the protocol more advantageous.

Synthesis of 3,4-dihydropyrimidin-2(1H)ones and 3,4,5,6,7,8- hexahydroquinazolin-2(1H)-ones via three component cyclocondensation

3,4 Dihydropyrimidin-2(1H)-ones and 3,4,5,6,7,8-hexahydroquinazolin-2(1H)- ones have been synthesized from the condensation of ketones, aldehydes and urea/thiourea in the presence of sodium tertiary butoxide by the solventless microwave irradiation (MWI)

New three-component cyclocondensation reaction: microwave-assisted one-pot synthesis of 5-unsubstituted-3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions

Sixteen 5-unsubstituted-3,4-dihydropyrimidin-2(1H)-ones have been synthesized by microwave-assisted Biginelli reactions in a short and concise manner employing ZnI2 as a catalyst under solvent-free conditions. All products were identified by IR

Aluminium(III) halides mediated synthesis of 5-unsustituted 3,4-dihydropyrimidin-2(1H)-ones via three component Biginelli-like reaction

5-Unsubstituted-3,4-dihydropyrimidin-2(1H)-ones have been synthesized in excellent yields in a aluminium(III) halides mediated three component cycloaddition of aldehyde, urea and enolizable ketone.