649756-12-7

Upstream product

• 649756-11-6 (2R,3S,4S)-3-triethylsilyloxy-5-(4-methoxybenzyloxy)-2,4-dimethyl-pentanoic acid 
• 74-88-4 methyl iodide 
• 398518-77-9 (2R,3S,4S)-3-hydroxy-5-(4-methoxybenzyloxy)-2,4-dimethylpentanoic acid 
• 496035-36-0 (2R,3S,4S)-3-hydroxy-5-(4-methoxybenzyloxy)-2,4-dimethylpentanal 
• 182193-69-7 (S)-1-(p-methoxybenzyloxy)-2-methylpentan-3-one 
• 133007-95-1 (2S,3R,4S)-5-[(4-methoxybenzyl)oxy]-2,4-dimethylpentane-1,3-diol 
• 827603-04-3 (2R,3R,4S,5S)-1-(tert-butyldimethylsilyloxy)-6-(4-methoxybenzyloxy)-3,5-dimethyl-hexane-2,4-diol 
• 827603-03-2 (2S,4S,5R)-6-(tert-butyldimethylsilyloxy)-5-hydroxy-1-(4-methoxybenzyloxy)-2,4-dimethylhexan-3-one 
• 496035-35-9 (2S,4S)-1-hydroxy-5-(p-methoxybenzyloxy)-2,4-dimethylpentan-3-one 
• 79271-56-0 triethylsilyl trifluoromethyl sulfonate 
• 496035-49-5 methyl (2R,3S,4S)-2,4-dimethyl-3-hydroxy-5-(4-methoxybenzyloxy)pentanoate 

Relevant academic research and scientific papers

A second-generation total synthesis of (+)-discodermolide: The development of a practical route using solely substrate-based stereocontrol

(Chemical Equation Presented). A novel total synthesis of the complex polyketide (+)-discodermolide, a promising anticancer agent of sponge origin, has been completed in 7.8% overall yield over 24 linear steps, with 35 steps altogether. This second-genera

SYNTHESIS OF DISCODERMOLIDE

The invention relates to a process for preparing discodermolide, for preparing intermediates for the manufacture of discodermolide and discodermolide analogues and to the intermediates obtained during the process. Wherein the process proceeds via a tetrae