496047-50-8

Upstream product

• 6620-80-0 N-isopropylbenzimidoyl chloride 
• 496047-45-1 7-(2-benzyloxy-4-methoxyphenyl)-6-tert-butoxycarbonyl-7-hydroxy-5-oxocyclopenteno[1,2-b]pyridine 
• 496047-46-2 7-(2-benzyloxy-4-methoxyphenyl)-6-tert-butoxycarbonyl-5-oxocyclopenta-1,3-dieno[2,1-b]pyridine 
• 496047-44-0 2-(2-benzyloxy-4-methoxybenzoyl)-3-[(1-imidazolyl)carbonyl]pyridine 
• 205640-56-8 2-benzyloxy-4-methoxyphenylmagnesium bromide 
• 164463-34-7 2-(2-benzyloxy-4-methoxybenzoyl)-3-pyridinecarboxylic acid 
• 150356-67-5 1-bromo-4-methoxy-2-(phenylmethoxy)benzene 
• 100-39-0 benzyl bromide 
• 63604-94-4 2-bromo-5-methoxyphenol 
• 540-88-5 acetic acid tert-butyl ester 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 169745-61-3 7-(2-benzyloxy-4-methoxyphenyl)-6-tert-butoxycarbonyl-5-(3,4-methylenedioxyphenyl)-5-hydroxycyclopenta-1,3-dieno[2,1-b]pyridine 

Relevant academic research and scientific papers

Convenient synthesis of 2-alkylamino-6-carboxy-5,7-diarylcyclopenteno[1,2- b]pyridines via direct acylamination with imidoyl chlorides

A robust synthetic method for 2-alkylamino-6-carboxy-5,7- diarylcyclopenteno[1,2-b]pyridines via acylamination at the alpha position of the functionalized pyridine system has been developed. The key step in this method was achieved by treatment of the corresponding pyridine N-oxides with 2.5 equiv of imidoyl chlorides in the presence of triethylamine, thus producing the desired 2-acylaminopyridines in good yields (74-96%).

A convenient synthetic method of a 5,7-diarylcyclopenteno-[1,2-b]pyridine-6-carboxylate: A key intermediate for potent endothelin receptor antagonists

A convenient synthetic method of 4, a key intermediate for a new class of endothelin receptor antagonists, was developed. Racemic 4 was synthesized from quinolinic anhydride in 13.4% overall yield without chromatographic purification.