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49656-78-2Relevant academic research and scientific papers
The dopamine, serotonin and norepinephrine releasing activities of a series of methcathinone analogs in male rat brain synaptosomes
Blough, Bruce E.,Decker, Ann M.,Landavazo, Antonio,Namjoshi, Ojas A.,Partilla, John S.,Baumann, Michael H.,Rothman, Richard B.
, p. 915 - 924 (2018/11/01)
Rationale: Novel synthetic “bath salt” cathinones continue to appear on the street as abused and addictive drugs. The range of subjective experiences produced by different cathinones suggests that some compounds have primarily dopaminergic activity (possi
Preparation methods for ephedrine or pseudoephedrine and for ephedrine or pseudoephedrine intermediate
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, (2017/04/14)
The invention discloses a preparation method for an ephedrine or pseudoephedrine intermediate. The preparation method comprises the following steps: with 2-chloropropionyl chloride and benzene as starting materials, carrying out the Friedel-Crafts reaction under the catalysis of Lewis acid so as to produce 2-chloro-1-phenyl-1-acetone; and reacting produced 2-chloro-1-phenyl-1-acetone with methylamine in an aprotic solvent so as to produce 2-methylamino-1-phenyl-1-acetone. The invention also discloses a preparation method for ephedrine or pseudoephedrine. According to the methods, phosphorus trichloride with severe pollution is not used anymore, and dangerous and expensive bromine is not used any longer; the Friedel-Crafts reaction and methylamination are carried out in the same solvent, so cost for public works is saved; and a safe, simple, cheap, green and novel process is provided for synthesis of ephedrine and pseudoephedrine.
The analysis of amphetamine-like cathinone derivatives using positive electrospray ionization with in-source collision-induced dissociation
Power, John D.,McDermott, Seán D.,Talbot, Brian,O'Brien, John E.,Kavanagh, Pierce
, p. 2601 - 2611 (2013/01/15)
Rationale: Amphetamine-like cathinone derivatives have become popular as recreational drugs over the past several years but their identification for forensic purposes is made difficult as they undergo extensive fragmentation under commonly used electron ionization (EI) conditions to afford ambiguous mass spectra. To overcome this, the feasibility of using positive electrospray ionization (ESI) with in-source collision-induced dissociation (CID) to produce distinguishable product ion mass spectra was examined. Methods: A set of six homologous cathinone derivatives was analyzed using an LTQ/Orbitrap high-resolution mass spectrometer to establish if there are any commonalities or uniqueness in their mass spectra. These compounds and a number of other cathinone derivatives were also analyzed on a single quadrupole mass spectrometer to establish the feasibility of using in-source CID for their identification in forensic drug samples. Results: The ESI product ion mass spectra of the [M + H]+ ions of six model compounds were found to be readily interpretable and product ion formation pathways are presented. The use of such mass spectral data in the analysis of forensic drug samples facilitated the discrimination of closely related cathinone derivatives that were difficult to distinguish using conventional gas chromatography/electron ionization mass spectrometry. A product ion mass spectral library of 22 commonly encountered cathinone derivatives was also developed. Conclusions: It has been shown that the product ion ESI mass spectra of cathinone derivatives are readily interpretable and are useful for the identification of this drug group in forensic samples. Copyright