497103-69-2

Upstream product

• 100-39-0 benzyl bromide 
• 497103-65-8 2-trifluoromethyl-3-[(4R)-N-[(1,1-dimethyl)ethoxycarbonyl]-2,2-dimethyl-1,3-oxazolidin-4-yl]propanol 
• 496848-29-4 ethyl 3-[(S)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidin-4-yl]-2-(trifluoromethyl)propanoate 

Downstream Products

• 497103-63-6 (2R,4S)-2-[N-(1,1-dimethyl)ethoxycarbonylamino]-1-tert-butyldimethylsilyloxy-5-benzyloxy-4-trifluoromethylpentane 
• 497103-64-7 (2R,4R)-2-[N-(1,1-dimethyl)ethoxycarbonylamino]-1-tert-butyldimethylsilyloxy-5-benzyloxy-4-trifluoromethylpentane 
• 497103-78-3 (2R,4S)-N-[(1,1-dimethyl)ethoxycarbonyl]-4-trifluoromethyl-D-proline 
• 497103-78-3 (2R,4R)-1-(tert-butoxycarbonyl)-4-(trifluoromethyl) pyrrolidine-2-carboxylic acid 
• 497103-70-5 (2R)-2-[N-(1,1-dimethyl)ethoxycarbonylamino]-5-benzyloxy-4-trifluoromethylpentanol 

Relevant academic research and scientific papers

Synthesis of Boc-protected cis- and trans-4-trifluoromethyl-D-prolines

Both Boc-protected trans- and cis-4-trifluoromethyl prolines were synthesized starting from L-serine simultaneously. In our synthetic route, the key intermediate 4 was obtained through the reaction of Garner's aldehyde 1 with ylide 2 followed by trifluoro