Synthesis of Boc-protected cis- and trans-4-trifluoromethyl-D-prolines

Article abstract of DOI:10.1039/b206719f

Both Boc-protected trans- and cis-4-trifluoromethyl prolines were synthesized starting from L-serine simultaneously. In our synthetic route, the key intermediate 4 was obtained through the reaction of Garner's aldehyde 1 with ylide 2 followed by trifluoro