497224-18-7Relevant academic research and scientific papers
Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: Synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety
Seto, Masaki,Aikawa, Katsuji,Miyamoto, Naoki,Aramaki, Yoshio,Kanzaki, Naoyuki,Takashima, Katsunori,Kuze, Yoji,Iizawa, Yuji,Baba, Masanori,Shiraishi, Mitsuru
, p. 2037 - 2048 (2007/10/03)
Chemical modification has been performed on an orally bioavailable and potent CCR5 antagonist, sulfoxide compound 4, mainly focusing on replacement of the [6,7]-fused 1-benzazepine nucleus. We designed, synthesized, and evaluated the biological activities
