4975-21-7Relevant academic research and scientific papers
4-[(4-(CARBOXYETHYL) PIPERIDINYL) METHYL] PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page 33; 25, (2010/02/07)
3-Substituted pyrrolidines having a 4-carboxypiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.
4(SPIROPIPERIDINYL)METHYL SUBSTITUTED PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page 42-43, (2010/02/07)
3-Substituted pyrrolidines having a spiropiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.
Organometallic synthesis in the furazan series 2. Furazanylethanes
Sheremetev,Ivanovo,Sizov,Kulagina,Dmitriev,Strelenko
, p. 679 - 688 (2007/10/03)
The reactions of Li derivatives of methylfurazans with electrophilic reagents and oxidants were investigated. A series of functionalized furazanylethane derivatives were prepared.
MORPHOLINE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND THEIR USE AS THERAPEUTIC AGENTS
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, (2008/06/13)
The present invention relates to compounds of formula (I), wherein R. sup.1 and R 4 represent hydrogen, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC. sub.1-4 alkyl, C 1-6 alkoxy, C 1-4 alkyl substituted by a hydroxy or C 1-4 alkoxy group, OCF 3, hydroxy, trifluoromethyl, trimethylsilyl, nitro, CN, SR a, SOR a, SO 2 R a, COR. sup.a, CO 2 R a or CONR a R b, where R. sup.a and R b are each independently hydrogen or C 1-4 alkyl; R. sup.2, R 3 and R 5 represent hydrogen, halogen, C 1-6 alkyl, C 1-4 alkoxy substituted by a C 1-4 alkoxy group, or trifluoromethyl; R 6 represents C 1-6 alkyl, optionally substituted by oxo, substituted by a 5-membered heteroaromatic ring selected from oxazole, thiazole, isoxazole, isothiazole, oxadiazole and thiadiazole, wherein each heteroaromatic ring is substituted at the available carbon atom by a group of the formula: ZNR 7 R 8. The compounds are of particular use in the treatment of pain, inflammation, migraine and emesis.
