49780-05-4

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 64-17-5 ethanol 
• 4998-15-6 4-chlorophenylglyoxal 
• 591-08-2 acetylthiourea 
• 33002-89-0 ethyl (2amino-4-p-chlorophenyl-thiazol-5-yl)acetate 

Relevant academic research and scientific papers

One-pot three-component reaction of arylglyoxals with acetylthiourea and Meldrum’s acid or barbituric acid for synthesis of new 2-acetamido-4-arylthiazol-5-yl derivatives

An efficient method for the synthesis of 2-acetamido-4-arylthiazol-5-yl derivatives via a novel one-pot three-component reaction of arylglyoxals, 1,3-dicarbonyl compounds such as Meldrum’s acid or barbituric acid, and acetylthiourea in ethanol is reported

5-Substituted 2-amino-4-arylthiazoles

5-Substituted 2-amino-4-arylthiazoles have interesting properties as anti-inflammatories, antipyretics, analgesics, antibacterials, C.N.S. depressants, anti-ulcer, and anti-cough agents.