497848-13-2

Upstream product

• 902453-94-5 4-(6-bromo-imidazo[1,2-a]pyridin-2-yl)-N,2-dimethylbenzenamine 
• 60-24-2 2-hydroxyethanethiol 
• 1291779-71-9 N-(4-(imidazo[1,2-a]pyridin-2-yl)-phenyl)-N-methyl-2,2,2-trifluoroacetamide 
• 1291779-70-8 N-(4-(imidazo[1,2-a]pyridin-2-yl)-phenyl)-2,2,2-trifluoroacetamide 
• 139705-74-1 2-(4-aminophenyl)imidazo<1,2-a>pyridine 
• 902453-96-7 C₅H₁₃NOSSn 
• 683768-16-3 4-(6-iodo-H-imidazo[1,2-a]pyridin-2-yl)-N-methylbenzenamine 
• 107-21-1 ethylene glycol 
• 758-08-7 Thioglycolamide 

Downstream Products

• 14954-72-4 2-(4′-dimethylaminophenyl)-6-imidazo[1,2-a]pyridine 
• 1291779-97-9 (1R,3S)-3-propionylamino-cyclopentanecarboxylic acid N-[4-(imidazo[1,2-a]pyridin-2-yl)phenyl]-N-methyl-amide 

Relevant academic research and scientific papers

Discovery of BI 99179, a potent and selective inhibitor of type i fatty acid synthase with central exposure

Based on a high-throughput screen, cyclopentanecarboxanilides were identified as a new chemotype of non-covalent inhibitors of type I fatty acid synthase (FAS). Starting from initial hits we aimed at generating a tool compound suitable for the in vivo validation of FAS as a therapeutic target. Optimisation yielded BI 99179 which is characterised by high potency, remarkably high selectivity and significant exposure (both peripheral and central) upon oral administration in rats.

BETA-AMYLOID PET IMAGING AGENTS

Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions for aryl thioethers in general that provides a high ratio of substitution relative to reduction and can be used for the imidazopyridinylbenzeneamine derivatives as well as other compounds of related structure.

Rapid palladium-catalyzed cross-coupling in the synthesis of aryl thioethers under microwave conditions

A Pd-catalyzed coupling of aromatic iodides or bromides and tin-thiolates under microwave conditions was developed to synthesize aromatic thioethers without concomitant formation of the reduced products. Ligand screening revealed DiPPF and BINAP-Tol as th

Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting β-amyloid plaques in the brain

A series of novel β-amyloid (Aβ) aggregate-specific ligands, 2-(4′-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine, 16(IMPY), and its related derivatives were prepared. An in vitro binding study with preformed Aβ aggregates showed that 16(IMPY) and its