498-81-7Relevant articles and documents
Biotransformation of one monoterpene by sporulated surface cultures of Aspergillus niger and Penicillium sp.
Esmaeili, Akbar,Sharafian, Shirin,Safaiyan, Shila,Rezazadeh, Shamsali,Rustaivan, Abdolhossein
, p. 1058 - 1061 (2009)
In this study, biotransformation of menthol by sporulated surface culture of Aspergillus niger and Penicillium sp. was studied. The main bioconversion product obtained from menthol of A. niger was cis-p-menthan-7-ol and the main products obtained by surfa
Discovery of a novel series of α-terpineol derivatives as promising anti-asthmatic agents: Their design, synthesis, and biological evaluation
Zhu, Wanping,Liu, Xia,Wang, Yuji,Tong, Yeling,Hu, Yongzhou
, p. 419 - 425 (2017/12/07)
A series of novel α-terpineol derivatives were designed and synthesized through structural derivatization of the tertiary hydroxyl moiety or reduction of the double bond. Of the resulting compounds, eight compounds enhanced relaxation of airway smooth muscle (ASM) compared to the α-terpineol precursor, and four compounds (4a, 4d, 4e, and 4i)were superior or comparable to aminophylline at a concentration of 0.75 mmol/L. Assays for 3′-5′-Cyclic adenosine monophpsphate (cAMP) activation revealed that some representative α-terpineol derivatives in this series were capable of upregulating the level of cAMP in ASM cells. Further in vivo investigation using the asthmatic rat model, illustrated that treatment with the compounds 4a and 4e resulted in significantly lowered lung resistance (RL) and enhanced dynamic lung compliance (Cldyn), two important parameters for lung fuction. Moreover, treatment with 4e downregulated the levels of both IL-4 and IL-17. Due to its several favorable physiological functions, including ASM relaxation activity, cAMP activation capability, and in vivo anti-asthmatic efficacy, 4e is a promising remedy for bronchial asthma, meriting extensive development.
meng Wanchun products and to a method for preparing the same
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Paragraph 0027; 0028; 0029; 0030, (2016/10/09)
The invention discloses a 1-isopropyl-4-methylcyclohexane product and a preparation method thereof. The method includes utilizing mixed gas composed of normal pressure air, oxygenized air or oxygen and inert gas as an oxidizing agent with the flowing speed as 10-100mL/min and the reaction temperature as 70-180 DEG C, utilizing metalloporphyrin or a solid carrier of the metalloporphyrin as a catalyst, conducting reaction under the condition that no additional solvent or oxidation reductant exists with the catalyst mass fraction as 1-100mg/kg and the reaction time as 1-24h and conducting rectification separation after reaction to obtain an the 1-isopropyl-4-methylcyclohexane product. Main components of the product include 1-isopropyl-4-methylcyclohexane-1-alcohol, 1-isopropyl-4-methylcyclohexane-2-alcohol, 1-isopropyl-4-methylcyclohexane-3-alcohol, 1-isopropyl-4-methylcyclohexane-4-alcohol, 1-isopropyl-4-methylcyclohexane-8-alcohol and a small amount of 1-isopropyl-4-methylcyclohexane-2-ketone and 1-isopropyl-4-methylcyclohexane-3-ketone. The method is less in catalyst usage, simple in reaction process, low in temperature, high in triggering speed, good in selectivity, capable of conducting homogeneous catalysis and also capable of conducting heterogeneous catalysis after immobilization.
Selective aerobic hydroxylation of p-menthane to dihydroterpineols catalyzed by metalloporphyrins in solvent and additive free system
Xu, Shichao,Zhao, Zhendong,Bi, Liangwu,Chen, Yuxiang,Li, Dongmei,Wang, Jing,Gu, Yan,Lu, Yanju
, p. 26 - 29 (2014/12/11)
Metallodeuteroporphyrins (MDPs) were employed as the catalysts for aerobic hydroxylation of p-menthane in absence of solvents and additives under ambient pressure. Tertiary C-H bonds were found to be more active than secondary and primary C-H bonds. Thus,
