4981-64-0

Basic information

• Product Name: 4'-Bromobutyrophenone
• Synonyms: 1-(4-bromophenyl)-1-butanon;1-Butanone, 1-(4-bromophenyl)-;Butyrophenone, 4'-bromo-;p-Bromobutyrophenone;4-BROMOBUTYROPHENONE;AURORA 22533;4-BROMOBUTYROPHENONE 98%;1-(4-bromophenyl)butan-1-one
• CAS NO: 4981-64-0
• Molecular Formula: C₁₀H₁₁BrO
• Molecular Weight: 227.1
• EINECS: 225-632-6
• Mol File: 4981-64-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 38-39 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 290.9 °C at 760 mmHg
• Flash Point: 71.2 °C
• Appearance: /
• Density: 1.334 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4'-Bromobutyrophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Bromobutyrophenone(4981-64-0)
• EPA Substance Registry System: 4'-Bromobutyrophenone(4981-64-0)

Safety Data

• Hazardous Substances Data: 4981-64-0(Hazardous Substances Data)

Usage

General Description

4'-Bromobutyrophenone is a chemical compound with the molecular formula C10H11BrO. It is a colorless to yellow liquid with a strong, sweet odor. 4'-Bromobutyrophenone is commonly used in the production of pharmaceuticals, particularly as a precursor for the synthesis of various medications. It is also used as an intermediate in the manufacturing of agrochemicals and other fine chemicals. Due to its potential hazards, including skin and eye irritation, as well as its potential to be harmful if ingested or inhaled, 4'-Bromobutyrophenone should be handled and stored with care, in accordance with appropriate safety measures and regulations.

InChI:InChI=1/C10H11BrO/c1-2-3-10(12)8-4-6-9(11)7-5-8/h4-7H,2-3H2,1H3

Upstream product

• 106-31-0 butanoic acid anhydride 
• 108-86-1 bromobenzene 
• 2234-82-4 1-propylmagnesium chloride 
• 586-75-4 4-chlorobenzoyl chloride 
• 109480-78-6 N-methoxy-N-methylbutanamide 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 5467-74-3 4-Bromophenylboronic acid 
• 632336-93-7 2-bromo-1-(4-bromophenyl)butan-1-one 
• 623-00-7 4-bromobenzenecarbonitrile 
• 64-18-6 formic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 106-94-5 propyl bromide 
• 104-51-8 1-butylbenzene 
• 106-37-6 1.4-dibromobenzene 

Downstream Products

• 38847-68-6 1-(4-bromo-phenyl)-butane-1,2-dione-2-oxime 
• 41492-05-1 p-bromobutylbenzene 
• 146781-56-8 p-Brom-α-propyl-benzylamin 
• 91715-78-5 4-Brom-3-nitrophenyl)-propylketon 
• 495-40-9 propiophenone 
• 875433-12-8 3-(4-bromo-benzoyl)-pentanoic acid ethyl ester 
• 927190-95-2 3-[4-(3-benzyloxy-prop-1-ynyl)-benzoyl]-pentanoic acid ethyl ester 
• 71293-48-6 (p-carboxyphenyl)triphenylphosphonium bromide 
• 20651-73-4 4-butylbenzonitrile 

Relevant articles and documents

Intramolecular N?H???F Hydrogen Bonding Interaction in a Series of 4-Anilino-5-Fluoroquinazolines: Experimental and Theoretical Characterization of Electronic and Conformational Effects

The 4-anilino-6,7-ethylenedioxy-5-fluoroquinazoline scaffold is presented as a novel model system for the characterization of the weak NH???F hydrogen bonding (HB) interaction. In this scaffold, the aniline NH proton is forced into close proximity with the nearby fluorine (dH,F～2.0 ?, ∠～138°), and a through-space interaction is observed by NMR spectroscopy with couplings (1hJNH,F) of 19±1 Hz. A combination of experimental (NMR spectroscopy and X-ray crystallography) and theoretical methods (DFT calculations) were used for the characterization of this weak interaction. In particular, the effects of conformational rigidity and steric compression on coupling were investigated. This scaffold was used for the direct comparison of fluoride with methoxy as HB acceptors, and the susceptibility of the NH???F interaction to changes in electron distribution and resonance was probed by preparing a series of molecules with different electron-donating or -withdrawing groups in the positions para to the NH and F. The results support the idea that fluorine can act as a weak HB acceptor, and the HB strength can be modulated through additive and linear electronic substituent effects.

Facile preparation of 5-alkyl-1-aryltetrazoles with arenes, acyl chlorides, hydroxylamine, and diphenylphosphoryl azide

Successive treatment of arenes with acyl chlorides and AlCl3, the addition of water and removal of solvent, the reaction with NH2OH?HCl and K2CO3, and the reaction with diphenylphosphoryl azide and DBU under warming conditions gave the corresponding 5-alkyl-1-aryltetrazoles efficiently in good to moderate yields. The present method is one-pot transformation of arenes into 5-alkyl-1-aryltetrazoles using the Friedel-Crafts acylation and the Beckmann rearrangement under transition-metal-free conditions.

Catalyst-Free Photodriven Reduction of α-Haloketones with Hantzsch Ester

Catalyst-free dehalogenation of α-haloketones under visible light irradiation is studied. The reactions were carried out in common organic solvent. The outcomes of dechlorination are excellent in yields up to 92%, and it is also applicable to bromides, which give even higher yields. The reaction is tolerable to a broad spectrum of substrates, especially to aromatic ketones, including various aryl and hetaryl groups. There are two examples of aliphatic ketones presented in the paper, although their reactivities are not as high as that of the aromatic ketones.