49864-98-4

Upstream product

• 77958-57-7 hexakis(4-formylphenoxy)cyclotriphosphazene 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 940-71-6 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 82280-42-0 1,1,3,3,5,5-hexakis(4-(bromomethyl)phenoxy)cyclotriphosphazene 
• 189074-30-4 hexakis[4-(chloromethyl)phenoxy]cyclotriphosphazene 

Relevant academic research and scientific papers

Phosphazene-cored star polymer bearing redox-active side groups as a cathode-active material in Li-ion batteries

A new hexa-armed star polymer bearing 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-pending polymer chains emanating from a phosphazene core (P2) was prepared and used as the cathode material in Li-ion battery assembly. The properties of the assembled battery (BP2) were compared with those of BL2 assembled using its linear counterpart (L2). Their spin concentrations investigated via solution electron spin resonance (ESR) measurements were found to be almost the same. The charge/discharge capacities and energy densities of BP2 were considerably higher than those of BL2. However, they exhibited comparable charge/discharge efficiencies and their discharge capacities dropped to similar percentages of their initial values.

A pH-Sensitive Drug Carrier Based on Maleic Acid-Substituted Cyclotriphosphazene

The cyclotriphosphazene derivative N3P3[OC6H4-p-CH2O(CO)CHCH(CO)OH]6 bearing maleic acid groups was synthesized and characterized by NMR, FTIR spectroscopy, and MS. A cross-linked network w

Synthesis, characterization, and activity of cyclotriphosphazene-cyclene conjugates

Two novel cyclotriphosphazene derivatives were synthesized from hexachloro cyclotriphosphzene. Their structures were characterized by 1H, 31P, and 13C NMR spectroscopy as well as by IR spectroscopy and electrospray ionizat

Safe Polycationic Dendrimers as Potent Oral in Vivo Inhibitors of Mycobacterium tuberculosis: A New Therapy to Take down Tuberculosis

The long-term treatment of tuberculosis (TB) sometimes leads to nonadherence to treatment, resulting in multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. Inadequate bioavailability of the drug is the main factor for therapeutic failure, which leads to the development of drug-resistant cases. Therefore, there is an urgent need to design and develop novel antimycobacterial agents minimizing the period of treatment and reducing the propagation of resistance at the same time. Here, we report the development of original and noncytotoxic polycationic phosphorus dendrimers essentially of generations 0 and 1, but also of generations 2-4, with pyrrolidinium, piperidinium, and related cyclic amino groups on the surface, as new antitubercular agents active per se, meaning with intrinsic activity. The strategy is based on the phenotypic screening of a newly designed phosphorus dendrimer library (generations 0-4) against three bacterial strains: attenuated Mycobacterium tuberculosis H37Ra, virulent M. tuberculosis H37Rv, and Mangora bovis BCG. The most potent polycationic phosphorus dendrimers 1G0,HCl and 2G0,HCl are active against all three strains with minimum inhibitory concentrations (MICs) between 3.12 and 25.0 μg/mL. Both are irregularly shaped nanoparticles with highly mobile branches presenting a radius of gyration of 7 ?, a diameter of maximal 25 ?, and a solvent-accessible surface area of dominantly positive potential energy with very localized negative patches arising from the central N3P3 core, which steadily interacts with water molecules. The most interesting is 2G0,HCl, showing relevant efficacy against single-drug-resistant (SDR) M. tuberculosis H37Rv, resistant to rifampicin, isoniaid, ethambutol, or streptomycin. Importantly, 2G0,HCl displayed significant in vivo efficacy based on bacterial counts in lungs of infected Balb/C mice at a dose of 50 mg/kg oral administration once a day for 2 weeks and superior efficacy in comparison to ethambutol and rifampicin. This series of polycationic phosphorus dendrimers represents first-in-class drugs to treat TB infection, could fulfill the clinical candidate pipe of this high burden of infectious disease, and play a part in addressing the continuous demand for new drugs.

Dual properties of water-soluble Ru-PTA complexes of dendrimers: Catalysis and interaction with DNA

Phosphorhydrazone dendrimers ended by PTA (1,3,5-triaza-7-phosphaadamantane) derivatives are used for the complexation of ruthenium. The corresponding complexes, either isolated (synthesized ex situ, i.e. preformed) or generated in situ are used as catalysts for the hydration of phenylacetylene in various conditions (ex situ or in situ, quantities, temperature, duration, co-catalyst or not, recycling). The same preformed complexes are tested for their interaction with supercoiled DNA, to afford relaxed DNA.

Preparation method of six-functionality epoxy resin based on cyclotriphosphazene

The invention discloses a preparation method of six-functionality epoxy resin based on cyclotriphosphazene, which aims at solving the technical problem of poor comprehensive property in the existing prepared epoxy resin flame-retardant system. The prepara

Cyclotriphosphazene type epoxy resin preparation method

The invention discloses a cyclotriphosphazene type epoxy resin preparation method. A purpose of the present invention is to solve the technical problem of poor practicability of the epoxy resin prepared through the existing method. The technical scheme co

Phosphazene based multicentered naked-eye fluorescent sensor with high selectivity for Fe3+ ions

A novel on/off fluorescent rhodamine-based hexapodal Fe3+ probe (L) containing a cyclotriphosphazene core was synthesized by an azide-alkyne "click-reaction". The synthesized compounds (1-5 and L) were characterized by FT-IR; 1H, 13C, and 31P NMR; and MALDI MS spectrometry. The optical sensor features for the Fe3+ complex of L were investigated by UV-vis and fluorescence spectroscopy. The stoichiometry of L-Fe3+ complex was found to be 1:3 (ligand/metal ion), and the detection limit of L was determined as 4.8 μM (0.27 mg L -1) for Fe3+ ions. The reusability of the sensor was tested by the addition of ethylenediamine to L-Fe3+ complex solutions followed by the addition of Fe3+ solution.

Radical-cation dimerization overwhelms inclusion in [N]pseudorotaxanes

Suppression of the dimerization of the viologen radical cation by cucurbit[7]uril (CB7) in water is a well-known phenomenon. Herein, two counter-examples are presented. Two viologen-containing thread molecules were designed, synthesized, and thoroughly ch

Design of bisphosphonate-terminated dendrimers

Several new methods for the synthesis of phosphorus dendrimers capped with biologically active azabisphosphonates are reported. Monomers bearing either azido or acetylenic groups were designed as building blocks either for attachment onto the surfaces of