499181-93-0Relevant academic research and scientific papers
METHODS FOR PREPARING ISOQUINOLINES
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Paragraph 00224, (2013/03/26)
Provided herein are novel synthetic methods of making isoquinolines comprising coupling a metalated N-(2-methylbenzylidene)amine with a nitrile, followed by cyclization, to provide a substituted isoquinoline compound. This new methodology for preparing is
A versatile synthesis of substituted isoquinolines
Si, Chong,Myers, Andrew G.
supporting information; experimental part, p. 10409 - 10413 (2011/12/03)
Lithiated o-tolualdehyde tert-butylimines were shown to condense with nitriles to form eneamido anion intermediates that were trapped in situ with various electrophiles, thus affording a diverse array of highly substituted isoquinolines, many of which are
Halopalladation cyclization of alkynes with azides: Selective synthesis of 4-haloisoquinolines and 3-haloindoles
Zhang, Hong-Ping,Yu, Shang-Ci,Liang, Yun,Peng, Peng,Tang, Bo-Xiao,Li, Jin-Heng
experimental part, p. 982 - 988 (2011/05/30)
A new, selective method for the synthesis of 4-haloisoquinolines and 3-haloindoles is presented by the halopalladation cyclizations of alkynes with azides. In the presence of PdX2 (X = Br, Cl) and halide sources, a variety of 2-alkynyl benzyl a
Synthesis of 4-(1-alkenyl)isoquinolines by palladium(II)-catalyzed cyclization/olefination
Huang, Qinhua,Larock, Richard C.
, p. 980 - 988 (2007/10/03)
A variety of 4-(1-alkenyl)-3-arylisoquinolines have been prepared in moderate to excellent yields by the Pd(II)-catalyzed cyclization of 2-(1-alkynyl)arylaldimines in the presence of various alkenes. The introduction of an o-methoxy group on the arylaldimine promotes the Pd-catalyzed cyclization and stabilizes the resulting Pd(II) intermediate, improving the yields of the isoquinoline products. Ketone-containing isoquinolines 36 and 49-51 have also been prepared by this process when unsaturated alcohols are employed as the alkenes.
