50-97-5

Basic information

• Product Name: HYDROBENZOLE HYDROCHLORIDE
• Synonyms: 2-(alpha-hydroxybenzyl)benzimidazole;alpha-phenyl-1h-benzimidazole-2-methano;alpha-phenyl-2-benzimidazolemethano;IFLAB-BB F1216-0101;HYDROBENZOLE HYDROCHLORIDE;1H-BENZIMIDAZOL-2-YL(PHENYL)METHANOL;TIMTEC-BB SBB000642;alpha-phenyl-1H-benzimidazole-2-methanol
• CAS NO: 50-97-5
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.26
• EINECS: 200-073-0
• Mol File: 50-97-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 207-208℃
• Boiling Point: 500.6°Cat760mmHg
• Flash Point: 256.5°C
• Appearance: /
• Density: 1.298g/cm³
• Vapor Pressure: 7.7E-11mmHg at 25°C
• Refractive Index: 1.709
• PKA: 11.37±0.10(Predicted)
• CAS DataBase Reference: HYDROBENZOLE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: HYDROBENZOLE HYDROCHLORIDE(50-97-5)
• EPA Substance Registry System: HYDROBENZOLE HYDROCHLORIDE(50-97-5)

Safety Data

• Hazardous Substances Data: 50-97-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 2949, 1989 DOI: 10.1021/jo00273a032

InChI:InChI=1/C14H12N2O/c17-13(10-6-2-1-3-7-10)14-15-11-8-4-5-9-12(11)16-14/h1-9,13,17H,(H,15,16)

Upstream product

• 3314-30-5 1H-benzoimidazole-2-carboxaldehyde 
• 591-51-5 phenyllithium 
• 100-52-7 benzaldehyde 
• 19213-18-4 1-pyrrolidin-1-ylmethyl-1H-benzoimidazole 
• 611-71-2 (R)-Mandelic Acid 
• 95-54-5 1,2-diamino-benzene 
• 51-17-2 benzoimidazole 
• 19541-99-2 benzoimidazol-1-yl-methanol 
• 611-71-2 MANDELIC ACID 
• 39145-59-0 o-phenylenediamine hydrochloride 

Downstream Products

• 1370428-18-4 2-[(1-methylpyrrolidin-3-yloxy)phenyl-methyl]-1H-benzimidazole 
• 55671-58-4 2-(chloro-phenyl-methyl)-1H-benzoimidazole 
• 1450934-18-5 4-phenylpyrido[1,2-a]benzimidazole 
• 1255651-24-1 3-ethoxycarbonyl-4-phenylpyrido[1,2-a]benzimidazole 
• 141229-88-1 dichloro-(2-α-oxybenzylbenzimidazolato-N,O)gallium(III) 
• 147-64-8 (1-benzyl-1H-benzoimidazol-2-yl)-phenyl-methanol 
• 17452-05-0 (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol 
• 3785-64-6 (1-ethyl-1H-benzoimidazol-2-yl)-phenyl-methanol 
• 944061-81-8 C₂₃H₂₀N₂O₂ 
• 33140-61-3 C₁₈H₁₈N₂O₂ 
• 944061-79-4 C₁₇H₁₆N₂O₂ 

Relevant articles and documents

NOVEL ONE-POT HOMOGENEOUS PROCESS FOR THE LARGE SCALE MANUFACTURE OF 2-SUBSTITUTED BENZIMIDAZOLES

2-substituted benzimidazoles and methods of preparing the same are disclosed. The compositions may include a compound or salt thereof, an acid, and a polar aprotic solvent. The compositions may be used to inhibit corrosion of a metal surface in contact with an aqueous system, and provide enhanced protection against corrosion of metals in the aqueous system.

BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS

The present patent application concerns new Iigands of the H4-receptor of formula (I), their process of preparation and their therapeutic use.

Boric acid-catalyzed direct condensation of carboxylic acids with benzene-1,2-diamine into benzimidazoles

The applicability of boric acid catalysis for the direct condensation of carboxylic acids with benzene-1,2-diamine to give 2-substituted benzimidazoles was investigated. It was found that catalytic amounts (5-10 mol-%) of boric acid efficiently promote the cyclocondensation of aliphatic carboxylic acids in refluxing toluene. In addition, the relatively neutral conditions allow the use of acid-sensitive substrates and give rise to specific transformations and selectivities that are not observed with some classical methods. Benzoic acids were found to be less reactive than aliphatic acids and thus require refluxing xylene for better efficiency. Phenylboronic acid was found to be inactive as a catalyst due to its rapid consumption by condensation with benzene-1,2-diamine to give a 2-phenylbenzodiazaborole. Copyright