17452-05-0

Basic information

• Product Name: (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol
• Synonyms: (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol;(1-methyl-1H-benzimidazol-2-yl)(phenyl)methanol
• CAS NO: 17452-05-0
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.28446
• Mol File: 17452-05-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol(17452-05-0)
• EPA Substance Registry System: (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol(17452-05-0)

Safety Data

• Hazardous Substances Data: 17452-05-0(Hazardous Substances Data)

Usage

General Description

"(1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol" is a chemical compound with a molecular formula C15H13N2O. It is a benzimidazolylphenylmethanol derivative, which may have potential pharmaceutical uses due to its structural properties. (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol contains a benzimidazole ring, a methyl group, a phenyl group, and a methanol group, which may contribute to its biological and chemical reactivity. Further research may be needed to explore the potential applications and properties of this compound in various fields including medicine and chemistry.

Upstream product

• 87772-40-5 Benzoic acid (1-methyl-1H-benzoimidazol-2-yl)-phenyl-methyl ester 
• 1632-83-3 1-Methylbenzimidazole 
• 100-52-7 benzaldehyde 
• 944061-79-4 C₁₇H₁₆N₂O₂ 
• 13745-35-2 (1-methyl-1H-benzo[d]imdiazol-2-yl)(phenyl)methanone 
• 50-97-5 (1H-benzimidazol-2-yl)phenylmethanol 
• 22841-76-5 acetoxy-(1H-benzoimidazol-2-yl)-phenyl-methane 
• 611-71-2 MANDELIC ACID 
• 4760-34-3 N-methyl-1,2-phenylenediamine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 612-28-2 2-nitro-N-methylaniline 

Downstream Products

• 187336-09-0 1-(1-Methyl-1H-benzoimidazol-2-yl)-1,2-diphenyl-ethanol 
• 19556-22-0 2-(methoxy(phenyl)methyl)-1-methyl-1H-benzo[d]imidazole 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 53458-14-3 2-(4-bromophenyl)-2-hydroxy-1-phenylethan-1-one 
• 59563-84-7 phenyl-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methanone 
• 195730-68-8 1-methyl-2-(α-benzyloxybenzyl)benzimidazole 

Relevant articles and documents

Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives

Benzimidazole and piperazines are the important pharmacophores in the structures of many antifungal compounds. Further, the phenylmethanone are also a unique class of compounds whose antifungal profile is not much exploited. So to exploit their antifungal potential we have selected these three combinations and framed the novel parent structure for our research work. In this study a novel series of benzimidazoles derivatives was synthesized by microwave irradiation and characterized by 1H NMR, 13C NMR, Infra Red (IR), and Mass Spectroscopy (MS), and by elemental analysis. The screening of compound for in vitro (turbidimetric method) antifungal activity against C.albicans revealed activity in many of the compounds as comparable to that of ketoconazole.

Alternate method for the synthesis of N-alkyl/aralkyl-2-(α-hydroxy alkyl/aralkyl)benzimidazoles via regiospecific acetylation

Acetylation of 1H-2-(α-hydroxyalkyl/aryl)benzimidazoles 2 with Ac2O results in the regiospecific formation of O-acetoxy derivative 3, which on alkylation with alkylating agents in nonaqueous media under phase-transfer catalytic conditions affords N-alkyl

Formation of deoxybenzoins from 1,3-dimethyl-2-(α-benzyloxybenzyl)benzimidazolium iodides through rearrangement followed by expulsion of azolium ylide

Treatment of several 1,3-dimethyl-2-(α-benzyloxybenzyl)benzimidazolium iodides 1 with K2CO3 gave deoxybenzoins 2 in moderate yields. Deoxybenzoins 2 were produced through rearrangement of benzyl groups followed by expulsion of 1,3-dimethylbenzimidazolium ylide (4). The reaction is classified as a Wittig rearrangement.