17452-05-0

Basic information

• Product Name: (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol
• Synonyms: (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol;(1-methyl-1H-benzimidazol-2-yl)(phenyl)methanol
• CAS NO: 17452-05-0
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.28446
• Mol File: 17452-05-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol(17452-05-0)
• EPA Substance Registry System: (1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol(17452-05-0)

Safety Data

• Hazardous Substances Data: 17452-05-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol is used as a potential pharmaceutical candidate for various applications due to its unique structural properties. Its benzimidazole ring, methyl group, phenyl group, and methanol group may contribute to its biological and chemical reactivity, making it a promising compound for the development of new drugs and therapies.
Used in Chemical Research:
(1-methyl-1H-benzo[d]imidazol-2-yl)(phenyl)methanol is used as a subject of chemical research to explore its potential applications and properties in various fields. Its unique structure and reactivity may provide valuable insights into the development of new chemical processes and technologies.

Upstream product

• 1632-83-3 1-Methylbenzimidazole 
• 100-52-7 benzaldehyde 
• 944061-79-4 C₁₇H₁₆N₂O₂ 
• 13745-35-2 (1-methyl-1H-benzo[d]imdiazol-2-yl)(phenyl)methanone 
• 611-71-2 MANDELIC ACID 
• 4760-34-3 N-methyl-1,2-phenylenediamine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 612-28-2 2-nitro-N-methylaniline 
• 22841-76-5 acetoxy-(1H-benzoimidazol-2-yl)-phenyl-methane 
• 50-97-5 (1H-benzimidazol-2-yl)phenylmethanol 
• 87772-40-5 Benzoic acid (1-methyl-1H-benzoimidazol-2-yl)-phenyl-methyl ester 

Downstream Products

• 59563-84-7 phenyl-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methanone 
• 53458-14-3 2-(4-bromophenyl)-2-hydroxy-1-phenylethan-1-one 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 19556-22-0 2-(methoxy(phenyl)methyl)-1-methyl-1H-benzo[d]imidazole 
• 187336-09-0 1-(1-Methyl-1H-benzoimidazol-2-yl)-1,2-diphenyl-ethanol 
• 195730-68-8 1-methyl-2-(α-benzyloxybenzyl)benzimidazole 

Relevant articles and documents

Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives

Benzimidazole and piperazines are the important pharmacophores in the structures of many antifungal compounds. Further, the phenylmethanone are also a unique class of compounds whose antifungal profile is not much exploited. So to exploit their antifungal potential we have selected these three combinations and framed the novel parent structure for our research work. In this study a novel series of benzimidazoles derivatives was synthesized by microwave irradiation and characterized by 1H NMR, 13C NMR, Infra Red (IR), and Mass Spectroscopy (MS), and by elemental analysis. The screening of compound for in vitro (turbidimetric method) antifungal activity against C.albicans revealed activity in many of the compounds as comparable to that of ketoconazole.

Structures and reactivities of O-methylated Breslow intermediates

As close as you can get: Since Breslow intermediates usually exist in their keto form, their O-protected tautomers may be considered as their closest isolable relatives. A series of these compounds have been synthesized, their structures determined, and the kinetics of their reactions with electrophiles investigated. Copyright

Alternate method for the synthesis of N-alkyl/aralkyl-2-(α-hydroxy alkyl/aralkyl)benzimidazoles via regiospecific acetylation

Acetylation of 1H-2-(α-hydroxyalkyl/aryl)benzimidazoles 2 with Ac2O results in the regiospecific formation of O-acetoxy derivative 3, which on alkylation with alkylating agents in nonaqueous media under phase-transfer catalytic conditions affords N-alkyl

Synthesis and reactivities of 1,3-dimethyl-2-(α-hydroxy-benzyl)imidazolium and 1,3-dimethyl-2-(α-hydroxybenzyl)benzimidazolium iodides

1,3-Dimethyl-2-(α-hydroxybenzyl)benzimidazolium iodide (3a) was synthesized from 1-methylbenzimidazole (10) through two steps involving lithiation and quaternization. Treatment of 3a with 4-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine (6) afforded 4-benzoyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine (15a). 4-Benzoylquinazoline (14a) and 7-benzoyl-3-phenyl-3H-1,2,3-triazolo[4,5-d]pyrimidine (16a) were given by reaction of 3a with 4-chloroquinazoline (5) and 7-chloro-3-phenyl-3H-1,2,3-triazolo[4,5-d]pyrimidine (7). Treatment of 3a with benzaldehyde (9a) gave benzoin (8a). Similar results were obtained in the reactions of 1,3-dimethyl-2-(α-hydroxybenzyl)imidazolium iodide (4a).

Formation of deoxybenzoins from 1,3-dimethyl-2-(α-benzyloxybenzyl)benzimidazolium iodides through rearrangement followed by expulsion of azolium ylide

Treatment of several 1,3-dimethyl-2-(α-benzyloxybenzyl)benzimidazolium iodides 1 with K2CO3 gave deoxybenzoins 2 in moderate yields. Deoxybenzoins 2 were produced through rearrangement of benzyl groups followed by expulsion of 1,3-dimethylbenzimidazolium ylide (4). The reaction is classified as a Wittig rearrangement.