500367-11-3

Upstream product

• 405-50-5 p-Fluorophenylacetic acid 
• 2999-46-4 Ethyl isocyanoacetate 
• 23012-14-8 oxazole-4-carboxylic acid ethyl ester 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 459-04-1 4-Fluorophenylacetyl chloride 

Downstream Products

• 93102-98-8 1-amino-3-(4-fluorophenyl)propan-2-one hydrochloride 
• 500367-12-4 C₁₁H₈FNO₃ 

Relevant academic research and scientific papers

Direct palladium-catalyzed alkenylation, benzylation and alkylation of ethyl oxazole-4-carboxylate with alkenyl-, benzyl- and alkyl halides

The ethyl oxazole-4-carboxylate was directly and regioselectively alkenylated, benzylated and alkylated with alkenyl-, benzyl-, allyl- and alkyl halides in the presence of catalytic amounts of palladium acetate with caesium carbonate using Buchwald's John

BICYCLIC PYRIMIDINONES AND USES THEREOF

The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compoundof Formula I is also provided.

ANTIVIRAL AGENT

The present invention provides an integrase inhibitor. The inventors have have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, R C and R D taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxy, mercapto or amino; Z is O, S or NH ; R A is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like)