500577-65-1 Usage
Uses
Used in Pharmaceutical Industry:
3,4-Dihydro-6-Methoxy-7-(phenylMethoxy)-1-[[4-(phenylMethoxy)phenyl]Methyl]-isoquinoline is used as an intermediate in the synthesis of Coclaurine (C633550), a benzyltetrahydroisoquinoline alkaloid extracted from Magnolia salicifolia. This alkaloid has potential applications in the development of new drugs and therapeutic agents, particularly in the treatment of various diseases and conditions.
Additionally, due to its unique molecular structure and functional groups, 3,4-Dihydro-6-Methoxy-7-(phenylMethoxy)-1-[[4-(phenylMethoxy)phenyl]Methyl]-isoquinoline may also be used as a building block or precursor in the synthesis of other complex organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its potential applications in these industries could lead to the discovery of new and innovative products with improved properties and performance.
Check Digit Verification of cas no
The CAS Registry Mumber 500577-65-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,0,5,7 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 500577-65:
(8*5)+(7*0)+(6*0)+(5*5)+(4*7)+(3*7)+(2*6)+(1*5)=131
131 % 10 = 1
So 500577-65-1 is a valid CAS Registry Number.
500577-65-1Relevant academic research and scientific papers
Designing new analogs for streamlining the structure of cytotoxic lamellarin natural products
Tangdenpaisal, Kassrin,Worayuthakarn, Rattana,Karnkla, Supatra,Ploypradith, Poonsakdi,Intachote, Pakamas,Sengsai, Suchada,Saimanee, Busakorn,Ruchirawat, Somsak,Chittchang, Montakarn
, p. 925 - 937 (2015/03/31)
Despite the therapeutic potential of marine-derived lamellarin natural products, their preclinical development has been hampered by their lipophilic nature, causing very poor aqueous solubility. In order to develop more drug-like analogs, their structure was streamlined in this study from both the cytotoxic activity and lipophilicity standpoints. First, a modified total synthetic route was successfully devised to construct a library of 59 systematically designed lamellarin analogs, which were then subjected to cytotoxicity and log P determinations. Along with the 25 first-generation lamellarins previously synthesized in our laboratory, the structure-activity and structure-lipophilicity relationships were extensively evaluated. Our results clearly indicated the additional structural requirements around the lamellarin skeleton which, when combined with those reported previously, can provide invaluable guidance for further modifications to increase the aqueous solubility of these compounds.
