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5021-52-3

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5021-52-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5021-52-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,2 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5021-52:
(6*5)+(5*0)+(4*2)+(3*1)+(2*5)+(1*2)=53
53 % 10 = 3
So 5021-52-3 is a valid CAS Registry Number.

5021-52-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-methyl-4H-[1,3]thiazolo[5,4-d]pyrimidine-5,7-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:5021-52-3 SDS

5021-52-3Relevant articles and documents

Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1 and A2A adenosine receptor antagonists/inverse agonists

Varano, Flavia,Catarzi, Daniela,Falsini, Matteo,Vincenzi, Fabrizio,Pasquini, Silvia,Varani, Katia,Colotta, Vittoria

, p. 3688 - 3695 (2018/06/06)

In this study a new set of thiazolo[5,4-d]pyrimidine derivatives was synthesized. These derivatives bear different substituents at positions 2 and 5 of the thiazolopyrimidine core while maintaining a free amino group at position-7. The new compounds were tested for their affinity and potency at human (h) A1, A2A, A2B and A3 adenosine receptors expressed in CHO cells. The results reveal that the higher affinity of these new set of thiazolopyrimidines is toward the hA1 and hA2A adenosine receptors subtypes and is tuned by the substitution pattern at both the 2 and 5 positions of the thiazolopyrimidine nucleus. Functional studies evidenced that the compounds behaved as dual A1/A2A antagonists/inverse agonists. Compound 3, bearing a 5-((2-methoxyphenyl) methylamino) group and a phenyl moiety at position 2, displayed the highest affinity (hA1 Ki = 10.2 nM; hA2A Ki = 4.72 nM) and behaved as a potent A1/A2A antagonist/inverse agonist (hA1 IC50 = 13.4 nM; hA2A IC50 = 5.34 nM).

Azole series. I. Reaction of 2-(acylamino)thioacetamides, leading to 5-aminothiazoles and to thiazolo[5,4-d]pyrimidines.

Sekiya,Osaki

, p. 1319 - 1325 (2007/10/07)

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