5023-65-4

Basic information

• Product Name: Benzene, 1-methyl-4-[(phenylthio)methyl]-
• CAS NO: 5023-65-4
• Molecular Formula: C14H14S
• Molecular Weight: 214.331
• Mol File: 5023-65-4.mol
• Article Data: 30

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methyl-4-[(phenylthio)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methyl-4-[(phenylthio)methyl]-(5023-65-4)
• EPA Substance Registry System: Benzene, 1-methyl-4-[(phenylthio)methyl]-(5023-65-4)

Safety Data

• Hazardous Substances Data: 5023-65-4(Hazardous Substances Data)

Upstream product

• 94-08-6 4-methylbenzoic acid ethyl ester 
• 112698-79-0 thexylphenylthioborane 
• 104-81-4 4-Methylbenzyl bromide 
• 4498-99-1 4-methylbenzylthiol 
• 59-88-1 phenylhydrazine hydrochloride 
• 14204-24-1 N-(phenylthio)succinimide 
• 106-42-3 para-xylene 
• 4052-88-4 4-methyl-N,N-dimethylbenzylamine 
• 882-33-7 diphenyldisulfane 
• 589-18-4 4-Methylbenzyl alcohol 
• 108-98-5 thiophenol 
• 40739-81-9 p-tolualdehyde p-toluenesulfonylhydrazone 
• 591-50-4 iodobenzene 
• 98-95-3 nitrobenzene 

Downstream Products

• 91969-52-7 2-(4’-methylphenyl)tetrahydrofuran 
• 356570-52-0 4,4,5,5-tetramethyl-2-[(4-methylphenyl)methyl]-1,3,2-dioxaborolane 
• 25079-96-3 N-(4-methylbenzyl)acetamide 
• 161104-35-4 (R)-(+)-4-methylbenzyl phenyl sulfoxide 
• 161104-36-5 (S)-(-)-4-methylbenzyl phenyl sulfoxide 
• 19523-24-1 1-methyl-4-((phenylsulfonyl)methyl)benzene 
• 538-39-6 1,2-di-p-tolylethane 
• 882-33-7 diphenyldisulfane 
• 106-42-3 para-xylene 
• 139-66-2 diphenyl sulfide 
• 104-87-0 4-methyl-benzaldehyde 

Relevant articles and documents

Photocatalytic synthesis method of aryl thioether and derivatives thereof

The invention belongs to the field of organic synthesis, and particularly relates to a photocatalytic synthesis method of aryl thioether and derivatives thereof. The synthesis method comprises the steps: dissolving an N-(sulfanyl) amide compound into a methyl aromatic compound under the protection of inert gas, and thus obtaining the aryl thioether compound under the action of light, a catalyst, aligand and alkali. According to the method, the coupling reaction of a C-S bond is completed through visible light induction by utilizing a light/Ni dual-catalytic system, so that the method has goodfunctional group compatibility, and the C-S bond compound can be selectively and efficiently constructed in one step. The method has the advantages of simple catalytic system, mild reaction conditions, economical, simple and easily available substrate, simple reaction operation and the like.

Transition metal-free coupling reactions of benzylic trimethylammonium salts with di(hetero)aryl disulfides and diselenides

A new protocol was developed to synthesize (enantioenriched) thioethers and selenoethers from (chiral) benzylic trimethylammonium salts and di(hetero)aryl disulfides or diselenides. These syntheses were promoted by the presence of weak base and did not require the use of any transition metal, and resulted in the target products with good to excellent yields (72-94%). Using quaternary ammonium salts synthesized from enantiomerically enriched amines led to highly enantiopure benzylic thioethers and selenoethers (94-99% ee) with configurations reversed from those of their enantioenriched quaternary ammonium salts. This journal is

Umpolung Difunctionalization of Carbonyls via Visible-Light Photoredox Catalytic Radical-Carbanion Relay

The combination of photoredox catalysis with the Wolff-Kishner (WK) reaction allows the difunctionalization of carbonyl groups by a radical-carbanion relay sequence (photo-Wolff-Kishner reaction). Photoredox initiated radical addition to N-sulfonylhydrazones yields α-functionalized carbanions following the WK-type mechanism. With sulfur-centered radicals, the carbanions are further functionalized by reaction with electrophiles including CO2 and aldehydes, whereas CF3 radical addition furnishes a wide range of gem-difluoroalkenes through β-fluoride elimination of the generated α-CF3 carbanions. More than 80 substrate examples demonstrate the broad applicability of this reaction sequence. A series of investigations including radical inhibition, deuterium labeling, fluorescence quenching, cyclic voltammetry, and control experiments support the proposed radical-carbanion relay mechanism.