5030-96-6Relevant articles and documents
Synthesis of bisindolylmethane, bispyrrolylmethane, and indolylpyrrolylmethane derivatives via reductive heteroarylation
Zhou, Hang,Huang, Zhuo,Huang, He,Song, Chuanjun,Chang, Junbiao
, (2021/07/25)
An efficient and general reductive heteroarylation approach toward the synthesis of bisindolylmethane, bispyrrolylmethane, and indolylpyrrolylmethane derivatives has been developed. Thus, treatment of acylpyrrole or acylindole derivatives with indoles or pyrroles in the presence of a combination of sodium borohydride and acetic acid resulted in the formation of the title compounds in moderate to excellent isolated yields.
Natural products for biocides discovery: Discovery of arundine and it's derivatives as novel antiviral and anti-phytopathogenic-fungus agents
Liao, Ancai,Jin, Shengli,Wang, Ziwen,Wang, Qingmin
, p. 195 - 206 (2020/06/18)
Plant diseases are one of the natural disasters that seriously harm agricultural production, and it is very difficult to control. The discovery of new antiviral and antifungal lead compounds becomes more and more important. Natural product arundine was found to have anti-tobacco mosaic virus (TMV) activity and anti-phytopathogenic-fungus activity for the first time. A series of arundine analogues were designed, synthesized and evaluated for their antiviral and fungicidal activities. Compound 6 with excellent antiviral activity emerged as novel antiviral lead compound. Compound 7 with 12.6?38.3 μg/mL EC50 values against 14 plant pathogens emerged as novel antifungal lead compound. This work laid a foundation for promoting the application of arundine analogues in plant protection.
Synthesis of Unnatural Arundines Using a Magnetically Reusable Copper Ferrite Catalyst
Ha, Pha T.,Nguyen, Oanh T. K.,Huynh, Khoa D.,Nguyen, Tung T.,Phan, Nam T. S.
supporting information, p. 2031 - 2034 (2018/09/18)
We report a method for copper ferrite-catalyzed coupling of indoles and N, N -dimethylacetamide (DMA) to afford Arundine derivatives. Halogen, methoxy, boronate ester, and trimethylsilyl functionalities are compatible with reaction conditions. Unprotected or sterically hindered indoles are also competent substrates. Indoles containing competitively reactive pyrazoles deliver the desired products in reasonable yields. The copper ferrite is easily recovered and reused, up to nine times without a significant yield loss.