503184-98-3Relevant academic research and scientific papers
Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase
Stelmach, John E.,Liu, Luping,Patel, Sangita B.,Pivnichny, James V.,Scapin, Giovanna,Singh, Suresh,Hop, Cornelis E. C. A.,Wang, Zhen,Strauss, John R.,Cameron, Patricia M.,Nichols, Elizabeth A.,O'Keefe, Stephen J.,O'Neill, Edward A.,Schmatz, Dennis M.,Schwartz, Cheryl D.,Thompson, Chris M.,Zaller, Dennis M.,Doherty, James B.
, p. 277 - 280 (2007/10/03)
The development of potent, orally bioavailable (in rat) and selective dihydroquinazolinone inhibitors of p38α MAP kinase is described. These analogues are hybrids of a pyridinylimidazole p38α inhibitor reported by Merck Research Laboratories and VX-745. O
