5033-23-8

Basic information

• Product Name: 1-(Phenylsulfonyl)piperidine, 97%
• Synonyms: 1-(Phenylsulfonyl)piperidine, 97%
• CAS NO: 5033-23-8
• Molecular Formula: C₁₁H₁₅NO₂S
• Molecular Weight: 225.3073
• Mol File: 5033-23-8.mol
• Article Data: 38

Chemical Properties

• Melting Point: 91.3-97 °C
• Boiling Point: 356.5°Cat760mmHg
• Flash Point: 169.4°C
• Appearance: /
• Density: 1.219g/cm³
• Vapor Pressure: 2.91E-05mmHg at 25°C
• Refractive Index: 1.569
• PKA: -4.73±0.20(Predicted)
• CAS DataBase Reference: 1-(Phenylsulfonyl)piperidine, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Phenylsulfonyl)piperidine, 97%(5033-23-8)
• EPA Substance Registry System: 1-(Phenylsulfonyl)piperidine, 97%(5033-23-8)

Safety Data

• Hazardous Substances Data: 5033-23-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 24, p. 205, 1994 DOI: 10.1080/00397919408013820

InChI:InChI=1/C11H15NO2S/c13-15(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1,3-4,7-8H,2,5-6,9-10H2

Upstream product

• 110-89-4 piperidine 
• 873-55-2 sodium benzenesulfonate 
• 35856-62-3 1-piperidinesulfonyl chloride 
• 71-43-2 benzene 
• 62-53-3 aniline 
• 80-17-1 benzenesufonyl hydrazide 
• 66003-76-7 Diphenyliodonium triflate 
• 591-50-4 iodobenzene 
• 98-09-9 benzenesulfonyl chloride 
• 108-98-5 thiophenol 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 5542-49-4 piperidin-1-yl benzoate 
• 1441409-82-0 (E)-ethyl 2-cyano-2-(phenylsulfonyloxyimino)acetate 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 133932-29-3 5-benzenesulfonylamino-valeric acid 
• 110-89-4 piperidine 
• 46855-40-7 5-(benzenesulfonyl-methyl-amino)-valeric acid 
• 98-09-9 benzenesulfonyl chloride 
• 106762-74-7 diphenyl<2-(piperidinosulfonyl)phenyl>methanol 

Relevant articles and documents

An efficient protocol for the selective reduction of benzenesulfonyllactam to benzenesulfonyl cyclic amine

The selective reduction of N-benzenesulfonylpiperidin-2-one to N-benzenesulfonylpiperidine was accomplished through the use of NaBH4 with either ZrCl4 or SnCl4 and by silane-mediated two-step reductions.

AEROBIC OXIDATIVE SYNTHESIS OF SULFONAMIDE USING Cu CATALYST

The present invention relates to a method for oxidative synthesis of sulfonamides using copper catalysts. , Oxygen (O) is used. 2 The oxidative synthesis of sulfonamides (1) comprises reacting a 2 th or sulfonyl hydrazide primary amine with a sulfonyl hydrazide (sulfonamide) with a copper catalyst on a solvent under the conditions in which the sulphonamide is fed. The oxidation coupling of the present invention showed extensive substrate ranges in an amine comprising a 2 primary amine, 1 primary amine and amine hydrochloride salt. It is worth notable that non-reactive aliphatic sulfonyl hydrazides in previously reported anaerobic systems can be used for the aerobic oxidation coupling of the present invention. The oxidation coupling of the present invention has been more effective on large scale.

Efficient and Practical Synthesis of Sulfonamides Utilizing SO2 Gas Generated on Demand

A simple and practical protocol was developed for the synthesis of sulfonamides by reacting organometallic reagents with SO2 gas generated on demand. SO2 was generated from readily available reagents safely in a highly contained and controlled fashion. The protocol allows the synthesis of sulfonamides without using either atom-inefficient SO2 surrogates or a SO2 cylinder that requires stringent storage regulations in the laboratory. The protocol was successfully applied to the synthesis of sildenafil.