50344-73-5Relevant academic research and scientific papers
N-Heterocyclic Carbene-Catalysed Mukaiyama-Michael Reaction and Mukaiyama Aldol/Mukaiyama-Michael Three-Component Coupling Reaction
Nguyen, Kim,Lupton, David W.
, p. 436 - 441 (2017)
An N-heterocyclic carbene-catalysed Mukaiyama-Michael addition between several trimethylsilyl (TMS) enol ethers and chalcone derivatives has been discovered. In addition, a related reaction cascade involving dehydrative Mukaiyama aldol followed by a Mukaiyama-Michael addition process has been developed. The later reaction can also be achieved as a three-component coupling reaction. The enantioselective variant of these reactions has been examined with homochiral catalysts. Though these catalysts were active, they fail to achieve enantioinduction.
In situ formed acetals facilitated direct Michael addition of unactivated ketones
Koppolu, Srinivasa Rao,Balamurugan, Rengarajan
, p. 1186 - 1192 (2017/02/10)
TfOH-promoted synthesis of 1,5-diketones by the Michael reaction of unactivated ketones with chalcones has been described. Acetals formed under HC(OMe)3/TfOH conditions generate the required enol-equivalents for a smooth Michael reaction. A wide array of symmetrical and unsymmetrical 1,5-diketones has been synthesised.
Bismuth Trichloride as a New Efficient Catalyst in the Aldol Reaction and the Michael Reaction
Wada, Makoto,Takeichi, Eiji,Matsumoto, Takashi
, p. 990 - 994 (2007/10/02)
In the presence of a catalytic amount of bismuth(III) trichloride (5 mol percent), silyl enol ethers react with aldehydes at room temperature in dichloromethane to give the corresponding aldols in good yields.Silyl enol ethers also have been found to reac
