50353-00-9

Basic information

• Product Name: 2-NITROPHENYL CHLOROFORMATE
• Synonyms: 2-NITROPHENYL CHLOROFORMATE;FHLXUWOHGKLDNF-UHFFFAOYSA-N
• CAS NO: 50353-00-9
• Molecular Formula: C₇H₄ClNO₄
• Molecular Weight: 201.56
• Product Categories: Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 50353-00-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 35-38 °C(lit.)
• Boiling Point: 132-133 °C7 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.5719 (rough estimate)
• Vapor Pressure: 0.00451mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• CAS DataBase Reference: 2-NITROPHENYL CHLOROFORMATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITROPHENYL CHLOROFORMATE(50353-00-9)
• EPA Substance Registry System: 2-NITROPHENYL CHLOROFORMATE(50353-00-9)

Safety Data

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 50353-00-9(Hazardous Substances Data)

Usage

General Description

2-Nitrophenyl chloroformate is a chemical compound with the molecular formula C7H4ClNO4. It is a clear yellow liquid that is used in organic synthesis as a reagent for the protection of amines and as a precursor for the synthesis of pharmaceuticals and agrochemicals. 2-NITROPHENYL CHLOROFORMATE is a reactive and versatile reagent, and it is widely used in the pharmaceutical industry as a building block for the synthesis of various drugs. Additionally, it is important to handle 2-nitrophenyl chloroformate with caution, as it is a potentially hazardous chemical that can cause irritation, burns, and other toxic effects if not handled properly.

InChI:InChI=1/C7H4ClNO4/c8-7(10)13-6-4-2-1-3-5(6)9(11)12/h1-4H

Upstream product

• 75-44-5 phosgene 
• 88-75-5 2-hydroxynitrobenzene 
• 824-39-5 sodium o-nitrophenate 

Downstream Products

• 112350-16-0 N-(2-nitro-phenoxycarbonyl)-DL-alanine 
• 108488-47-7 N-(2-nitro-phenoxycarbonyl)-L-leucine 
• 81420-42-0 mononitrophenyl carbonate 
• 98550-05-1 nitrophenyl carbamate 
• 117877-31-3 N-(2-nitro-phenoxycarbonyl)-glycine ethyl ester 
• 38235-26-6 o-Nitrophenoxycarbonyldimethyldithiocarbamat 
• 91390-32-8 2-nitrophenyl (2-fluoroethyl)carbamate 
• 88-75-5 2-hydroxynitrobenzene 
• 202996-37-0 Carbonic acid (3,5-dimethoxy-phenyl)-(2-phenyl-[1,3]dithian-2-yl)-methyl ester 2-nitro-phenyl ester 
• 193139-64-9 4-(tert-Butyl-dimethyl-silanyloxymethyl)-2-ethynyl-2H-quinoline-1-carboxylic acid 2-nitro-phenyl ester 
• 193139-73-0 2-ethynyl-1,2-dihydro-4-hydroxymethyl-1-(2-nitrophenyloxycarbonyl)quinoline 
• 107892-30-8 N-(2-nitro-phenoxycarbonyl)-glycine 
• 446018-26-4 1,4-diaza-bicyclo[3.2.2]nonane-4-carboxylic acid 2-nitro-phenyl ester 
• 485798-58-1 4-(1-Ethylpropyl)piperazine-1-carboxylic Acid 2-nitrophenyl Ester Hydrochloride Salt 

Relevant articles and documents

A safe and efficient route for the preparation of nitro-, dinitro-, and trinitrophenyl chloroformates

A safe and simple method has been developed for synthesis of chloroformates derived from 2-nitrophenol, 4-nitrophenol, 2,4-dinitrophenol, 2,4,6-trinitrophenol, and pentafluorophenol, the yields being in the range of 72-96%. The method is based on a heterogeneous reaction of the substituted phenol with phosgene dissolved in dichloromethane catalyzed with solid anhydrous potassium carbonate. The synthesis of 2,4,6-trinitrophenyl chloroformate takes place only in the presence of a phase-transfer catalyst, in this case the easily recovered α,ω-dimethoxy poly(ethylene glycol) (PEG; M = 2kDa). The only waste products of the suggested synthesis of the mentioned esters are sodium chloride and potassium chloride. The method markedly reduces the explosion risk connected with drying and handling of salts of mono-, di-, and trinitrophenols and is much more environmentally friendly than the currently used methods. Copyright