503560-05-2

Upstream product

• 118399-90-9 2-(12-bromododecyl)-2-methyl-1,3-dioxolane 
• 503560-09-6 3-((4S,trans)-4,5-dihydro-4-methyl-2-phenyloxazol-5-yl)-N-methoxy-N-methyl propionamide 
• 37865-96-6 2-(2-bromoethyl)-2-methyl-1,3-dioxolane 
• 4101-68-2 1,10-dibromodecane 
• 208935-32-4 (4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazoline 
• 503560-10-9 N-[2-(tert-butyl-dimethyl-silanyloxy)-1-formyl-ethyl]-benzamide 
• 482315-18-4 N-[(1S)-2-hydroxy-1-(tert-butyldimethylsilanyloxymethyl)-3-butenyl]-benzamide 
• 497227-95-9 N-((1S)-2-acetoxy-1-(tert-butyldimethylsilanyloxymethyl)-3-butenyl)-benzamide 
• 503560-12-1 3-(4-hydroxymethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-N-methoxy-N-methyl-propionamide 
• 503560-13-2 3-(4-iodomethyl-2-phenyl-4,5-dihydro-oxazol-5-yl)-N-methoxy-N-methyl-propionamide 
• 503560-07-4 (2E)-3-((4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazol-5-yl)-acrylic acid methyl ester 
• 503560-08-5 3-((4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazol-5-yl)-propionic acid methyl ester 
• 503560-11-0 3-[(4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazol-5-yl]-propionic acid 
• 503560-06-3 3-((4S,trans)-4,5-dihydro-4-(tert-butyldimethylsilanyloxymethyl)-2-phenyloxazol-5-yl)-N-methoxy-N-methyl-propionamide 

Relevant academic research and scientific papers

Stereoselective synthesis of (+)-spectaline

Our synthesis of (+)-spectaline revealed that the methodology involving diastereoselective palladium(0)-catalyzed oxazoline formation and intramolecular reductive amination by catalytic hydrogenation of an oxazoline is an effective method for the asymmetric synthesis of natural products possessing complex functionalized piperidine cores.