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504-97-2

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504-97-2 Usage

General Description

Sanshool is a naturally occurring chemical compound found in plants of the Zanthoxylum genus, particularly in the Sichuan peppercorn. It is responsible for the unique tingling and numbing sensation experienced when consuming Sichuan peppercorns or other foods containing Sanshool. Sanshool is known to activate the touch receptors in the mouth, leading to the perception of a tingling or buzzing sensation. This sensation is often described as similar to mild electrical shock or vibration and can enhance the overall sensory experience of food. In addition to its culinary applications, Sanshool has also been studied for its potential medicinal properties, such as possibly serving as a natural pain reliever.

Check Digit Verification of cas no

The CAS Registry Mumber 504-97-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 504-97:
(5*5)+(4*0)+(3*4)+(2*9)+(1*7)=62
62 % 10 = 2
So 504-97-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H25NO/c1-4-5-6-7-8-9-10-11-12-13-16(18)17-14-15(2)3/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,17,18)/b5-4+,7-6+,9-8-,13-12+

504-97-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (2E,6Z,8E,10E)-N-(2-methylpropyl)dodeca-2,6,8,10-tetraenamide

1.2 Other means of identification

Product number -
Other names 2t,6c,8t,10t-Dodecatetraensaeure-isobutylamid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:504-97-2 SDS

504-97-2Synthetic route

(2E,8E,10E)-N-isobutyldodeca-2,8,10-trien-6-yneamide

(2E,8E,10E)-N-isobutyldodeca-2,8,10-trien-6-yneamide

Alpha-Sanshool
504-97-2

Alpha-Sanshool

Conditions
ConditionsYield
With copper diacetate; silver nitrate; zinc In methanol; water for 24h;53%
2E,6Z,8E,10E-dodecatetraenoic acid
18744-21-3

2E,6Z,8E,10E-dodecatetraenoic acid

isobutylamine
78-81-9

isobutylamine

Alpha-Sanshool
504-97-2

Alpha-Sanshool

Conditions
ConditionsYield
(i) (COCl)2, (ii) /BRN= 385626/, Et3N; Multistep reaction;
trans,trans-2,4-Hexadienal
142-83-6

trans,trans-2,4-Hexadienal

(E)-6-(Triphenyl-λ5-phosphanylidene)-hex-2-enoic acid isobutyl-amide
98095-55-7

(E)-6-(Triphenyl-λ5-phosphanylidene)-hex-2-enoic acid isobutyl-amide

A

Alpha-Sanshool
504-97-2

Alpha-Sanshool

B

Beta-Sanshool
10076-00-3

Beta-Sanshool

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; dimethyl sulfoxide at 0℃; Yield given. Yields of byproduct given;
trans,trans-2,4-Hexadienal
142-83-6

trans,trans-2,4-Hexadienal

Alpha-Sanshool
504-97-2

Alpha-Sanshool

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaOEt, NaI
2: KOH
4: (i) (COCl)2, (ii) /BRN= 385626/, Et3N
View Scheme
Decatrien-(4cis.6trans.8trans)-saeure
18744-20-2

Decatrien-(4cis.6trans.8trans)-saeure

Alpha-Sanshool
504-97-2

Alpha-Sanshool

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: (i) (COCl)2, (ii) /BRN= 385626/, Et3N
View Scheme
Decatrien-(4cis.6trans.8trans)-saeureethylester
18744-19-9

Decatrien-(4cis.6trans.8trans)-saeureethylester

Alpha-Sanshool
504-97-2

Alpha-Sanshool

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: KOH
3: (i) (COCl)2, (ii) /BRN= 385626/, Et3N
View Scheme
hept-2-en-6-ynoic acid methyl ester
140677-99-2, 141943-16-0, 140677-83-4

hept-2-en-6-ynoic acid methyl ester

Alpha-Sanshool
504-97-2

Alpha-Sanshool

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium hydroxide / tetrahydrofuran / 1 h / 50 °C
2: N-ethyl-N,N-diisopropylamine; diethyl cyanophosphonate / tetrahydrofuran / 1.5 h / 0 - 20 °C
3: N-Bromosuccinimide; silver nitrate / acetone / 2 h / 20 °C
4: tetrakis(triphenylphosphine) palladium(0); sodium hydroxide / tetrahydrofuran / 2 h / 50 °C
5: silver nitrate; zinc; copper diacetate / water; methanol / 24 h
View Scheme
(E)-hept-2-en-6-ynoic acid
101861-38-5, 121318-58-9

(E)-hept-2-en-6-ynoic acid

Alpha-Sanshool
504-97-2

Alpha-Sanshool

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine; diethyl cyanophosphonate / tetrahydrofuran / 1.5 h / 0 - 20 °C
2: N-Bromosuccinimide; silver nitrate / acetone / 2 h / 20 °C
3: tetrakis(triphenylphosphine) palladium(0); sodium hydroxide / tetrahydrofuran / 2 h / 50 °C
4: silver nitrate; zinc; copper diacetate / water; methanol / 24 h
View Scheme
(E)-N-(2-methylpropyl)-2-hepten-6-ynamide
138691-20-0

(E)-N-(2-methylpropyl)-2-hepten-6-ynamide

Alpha-Sanshool
504-97-2

Alpha-Sanshool

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-Bromosuccinimide; silver nitrate / acetone / 2 h / 20 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium hydroxide / tetrahydrofuran / 2 h / 50 °C
3: silver nitrate; zinc; copper diacetate / water; methanol / 24 h
View Scheme
maleic anhydride
108-31-6

maleic anhydride

Alpha-Sanshool
504-97-2

Alpha-Sanshool

(+/-)-3c-(6t-isobutylcarbamoyl-hexa-1,5-dien-c-yl)-6c-methyl-cyclohex-4-ene-1r,2c-dicarboxylic acid-anhydride
102461-89-2

(+/-)-3c-(6t-isobutylcarbamoyl-hexa-1,5-dien-c-yl)-6c-methyl-cyclohex-4-ene-1r,2c-dicarboxylic acid-anhydride

Conditions
ConditionsYield
With benzene
Alpha-Sanshool
504-97-2

Alpha-Sanshool

Beta-Sanshool
10076-00-3

Beta-Sanshool

Conditions
ConditionsYield
With iodine; Petroleum ether Irradiation.mit Gluehlampenlicht;
With hexane; iodine Irradiation.mit Gluehlampenlicht;
With iodine
With iodine In hexane for 1h; Irradiation;190 mg
diethyl ether
60-29-7

diethyl ether

Alpha-Sanshool
504-97-2

Alpha-Sanshool

palladium

palladium

N-(2-methylpropyl)dodecanamide
68125-01-9

N-(2-methylpropyl)dodecanamide

Conditions
ConditionsYield
Hydrogenation;
Alpha-Sanshool
504-97-2

Alpha-Sanshool

acetic acid
64-19-7

acetic acid

palladium

palladium

N-(2-methylpropyl)dodecanamide
68125-01-9

N-(2-methylpropyl)dodecanamide

Conditions
ConditionsYield
Hydrogenation;

504-97-2Downstream Products

504-97-2Relevant articles and documents

Method for producing sanshool

-

, (2017/02/23)

PROBLEM TO BE SOLVED: To provide a short-step, highly stereoselective method for producing sanshools, and an alkyne derivative that is an intermediate useful for the method.SOLUTION: The alkyne derivative is represented by general formula (I), wherein Arepresents a halogen atom; and R represents a hydrogen atom, hydroxy or methyl. The method for producing sanshools uses this alkyne derivative, and comprises a step of cross-coupling reacting the alkyne derivative with a boronic acid derivative.

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