68125-01-9

Usage

Uses

Used in Personal Care Industry:
N-(2-methylpropyl)dodecanamide is used as an emulsifier and surfactant for its ability to stabilize oil-water emulsions, enhancing the texture and consistency of cosmetics, shampoos, and skin care products.
Used in Household Products Industry:
N-(2-methylpropyl)dodecanamide is used as an emulsifier and surfactant to improve the stability and performance of household products that require oil-water emulsion stabilization.
Used in Industrial Applications:
N-(2-methylpropyl)dodecanamide is used as a lubricant and corrosion inhibitor, providing protective properties in various industrial processes.
Used in Antimicrobial Products:
N-(2-methylpropyl)dodecanamide is used as a preservative and antimicrobial agent due to its antimicrobial properties, making it suitable for products that require protection against microbial growth.

Upstream product

• 360762-35-2 (2E,4E,8Z,10E/Z)-N-isobutyldodeca-2,4,8,10-tetraenamide 
• 60-29-7 diethyl ether 
• 504-97-2 Alpha-Sanshool 
• 64-19-7 acetic acid 
• 145427-75-4 N-isobutyldodeca-2,4-dienamide 
• 112-16-3 n-dodecanoyl chloride 
• 78-81-9 isobutylamine 
• 143-07-7 lauric acid 

Relevant academic research and scientific papers

Isobutyramide derivative and application thereof

The present invention relates to the technical field of cosmetics, and particularly relates to an isobutyramide derivative compound and an application thereof. The obtained compound can be used for preparing a cosmetic reagent or a pharmaceutical reagent by preparing the series compound which has antihistamine and inhibits skin erythema, pruritus and hyaluronidase. The cosmetic reagent and the pharmaceutical reagent are not specifically limited. For example, the reagents can be washing cosmetics such as skin softening lotion, nutritional lotion, massage cream, body lotion, gel, nutritional cream, facial masks and hair gel or bath cream shampoo, and also can be drug preparation products such as similar cream, ointment, cream, plaster or spray; and when the compound is used for the sensitiveskin, infant and child cosmetics can be also added with the compound to reduce irritation.

ALKAMIDE COMPOUNDS AND USES THEREOF

The present disclosure relates to alkamide compounds and compositions for treating allergic diseases, pain, or itch.

Effects of synthetic alkamides on Arabidopsis fatty acid amide hydrolase activity and plant development

Alkamides and N-acylethanolamines (NAEs) are bioactive, amide-linked lipids that influence plant development. Alkamides are restricted to several families of higher plants and some fungi, whereas NAEs are widespread signaling molecules in both plants and animals. Fatty acid amide hydrolase (FAAH) has been described as a key contributor to NAE hydrolysis; however, no enzyme has been associated with alkamide degradation in plants. Herein reported is synthesis of 12 compounds structurally similar to a naturally occurring alkamide (N-isobutyl-(2E,6Z,8E)decatrienamide or affinin) with different acyl compositions more similar to plant NAEs and various amino alkyl head groups. These "hybrid" synthetic alkamides were tested for activity toward recombinant Arabidopsis FAAH and for their effects on plant development (i.e., cotyledon expansion and primary root length). A substantial increase in FAAH activity was discovered toward NAEs in vitro in the presence of some of these synthetic alkamides, such as N-ethyllauroylamide (4). This "enhancement" effect was found to be due, at least in part, to relief from product inhibition of FAAH by ethanolamine, and not due to an alteration in the oligomerization state of the FAAH enzyme. For several of these alkamides, an inhibition of seedling growth was observed with greater results in FAAH knockouts and less in FAAH over-expressing plants, suggesting that these alkamides could be hydrolyzed by FAAH in planta. The tight regulation of NAE levels in vivo appears to be important for proper seedling establishment, and as such, some of these synthetic alkamides may be useful pharmacological tools to manipulate the effects of NAEs in situ.

Synthesis and biological evaluation of a series of fatty acid amides from Echinacea

Abstract Alkylamides are lipophilic constituents of Echinacea and possess numerous biological activities. Although significant effort has been focused on the study of crude Echinacea extracts, very little is known regarding the activities of the individual constituents that make up these herbal treatments. Herein we explore the SAR of simple alkylamides found in Echinacea extracts with respect to their ability to decrease the production of the pro-inflammatory mediator TNF-α. Our results have revealed the key structural requirements for activity and provide lead compounds for further investigation of these poorly understood molecules.

GC/MS investigations of the minor constituents of Piper guineense stem

Chemical investigations by GC/MS-analysis of stem extracts of Piper guineense resulted in the detection and identification of thirty-nine new constituents of the stem, apart from previously isolated constituents. These are isobutyl, pyrrolidyl and piperidyl amide alkaloids. Fifteen new natural products have been identified. Four of these natural products have been designated iyeremide A and B (these are pyrrolidine and piperidine analogues of pellitorine) and cycloguineense A and B, which are also piperidine analogues of cyclostachine A and B. There is a need to confirm the structures of some of these new constituents by synthesis. Apart from these amide alkaloids, many volatile oil components-monoterpenes, sesquiterpenes, terpenoids, lignans and sterols - were detected.