504414-61-3Relevant academic research and scientific papers
Cu(II)-catalyzed enantioselective aldol condensation between malonic acid hemithioesters and aldehydes
Orlandi, Simonetta,Benaglia, Maurizio,Cozzi, Franco
, p. 1747 - 1749 (2004)
A mild, decarboxylative, aldol-type addition of malonic acid hemithioesters to aldehydes has been shown to occur with up to 39% enantioselectivity when the reaction was carried out in the presence of catalytic amounts of a Cu(II) salt, an enantiopure, tartaric acid-derived bis-benzimidazole and an achiral base.
An exceptionally mild catalytic thioester aldol reaction inspired by polyketide biosynthesis
Lalic, Gojko,Aloise, Allen D.,Shair, Matthew D.
, p. 2852 - 2853 (2007/10/03)
This report details our discovery of a new catalytic ester aldol reaction using malonic acid half thioesters (MAHTs) that directly affords β-hydroxythioesters. The reaction is catalyzed by combination of a Cu(II) salt and an amine base, and it can be perf
