50499-60-0

Basic information

• Product Name: (+)-4-amino-alpha-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol
• Synonyms: (S)-Clenbuterol;Benzenemethanol, 4-amino-3,5-dichloro-α-[[(1,1-dimethylethyl)amino]methyl]-, (S)-;Benzenemethanol, 4-amino-3,5-dichloro-α-[[(1,1-dimethylethyl)amino]methyl]-, (αS)-;(aS)-4-Amino-3,5-dichloro-α-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol;(aS)-4-Amino-3,5-dichloro-a-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol;(S)-4-Amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzenemethanol;Einecs 256-608-3;(αS)-4-AMino-3,5-dichloro-α-[[(1,1-diMethylethyl)aMino]Methyl]benzeneMethanol
• CAS NO: 50499-60-0
• Molecular Formula: C12H18Cl2N2O
• Molecular Weight: 277.1932
• EINECS: 256-608-3
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Einecs 256-608-3;Benzenemethanol
• Mol File: 50499-60-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 125-128°C
• Appearance: /
• Storage Temp.: Refrigerator
• CAS DataBase Reference: (+)-4-amino-alpha-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-4-amino-alpha-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol(50499-60-0)
• EPA Substance Registry System: (+)-4-amino-alpha-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol(50499-60-0)

Safety Data

• Hazardous Substances Data: 50499-60-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 50499-60-0 differently. You can refer to the following data:
1. (S)-Enantiomer of Clenbuterol. Substituted phenylethanolamine with β2 sympathomimetic activity. Bronchodilator.
2. (S)-Enantiomer of Clenbuterol. Substituted phenylethanolamine with 2 sympathomimetic activity. Bronchodilator

InChI:InChI=1/C12H18Cl2N2O/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7/h4-5,10,16-17H,6,15H2,1-3H3

Upstream product

• 37148-27-9 clenbuterol 
• 37148-48-4 1-(4-amino-3,5-dichlorophenyl)-1-ethanone 
• 99-92-3 p-aminobenzophenone 
• 37148-47-3 1-(4-amino-3,5-dichlorophenyl)-2-bromoethan-1-one 
• 75-64-9 tert-butylamine 
• 697-89-2 2,6-dichloro-4-iodoaniline 
• 75136-79-7 2-(4-amino-3,5-dichlorophenyl)-N-(tert-butyl)-2-oxoacetamide 
• 37845-71-9 4'-amino-2-(t-butylamino)-3',5'-dichloroacetophenone hydrochloride 
• 56138-70-6 rac-1-(4-aminophenyl)-2-(tert-butylamino)ethanol 

Relevant articles and documents

Preparation of a novel hydroxypropyl-γ-cyclodextrin functionalized monolith for separation of chiral drugs in capillary electrochromatography

In this study, a novel hydroxypropyl-γ-cyclodextrin (HP-γ-CD) functionalized monolithic capillary column was prepared by one-pot sequential strategy and used for chiral separation in capillary electrochromatography for the first time. In one pot, GMA-HP-γ-CD as functional monomer was allowed to be formed via the ring opening reaction between HP-γ-CD and glycidyl methacrylate (GMA) catalyzed by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and then copolymerized directly with ethylene dimethacrylate (EDMA) and 2-acrylamido-2-methyl propane sulfonic acid (AMPS) in the presence of porogenic solvents via thermally initiated free radical polymerization. The preparation conditions of monoliths were optimized. Enantiomer separations of six chiral drugs including pindolol, clorprenaline, tulobuterol, clenbuterol, propranolol, and tropicamide were achieved on the monolith. Among them, pindolol, clorprenaline, and tropicamide were baseline separated with resolution values of 1.62, 1.73, and 1.55, respectively. The mechanism of enantiomer separation was discussed by comparison of the HP-γ-CD and HP-β-CD functionalized monoliths.

Functionalities tuned enantioselectivity of phenylcarbamate cyclodextrin clicked chiral stationary phases in HPLC

The mixed chloro- and methyl- functionalities can greatly modulate the enantioselectivities of phenylcarbamate cyclodextrin (CD) clicked chiral stationary phases (CSPs). A comparison study is herein reported for per(4-chloro-3-methyl)phenylcarbamate and per(2-chloro-5-methyl)phenylcarbamate β-CD clicked CSPs (i.e., CCC4M3-CSP and CCC2M5-CSP). The enantioselectivity dependence on column temperature was studied in both normal-phase and reversed-phase mode high performance liquid chromatography (HPLC). The thermodynamic study revealed that the stronger intermolecular interactions can be formed between CCC4M3-CSP and chiral solutes to drive the chiral separation. The higher enantioselectivities of CCC4M3-CSP were further demonstrated with the enantioseparation of 17 model racemates in HPLC.

Palladium-catalyzed double carbonylation using near stoichiometric carbon monoxide: Expedient access to substituted 13C2-labeled phenethylamines

A novel and general approach for 13C2- and 2H-labeled phenethylamine derivatives has been developed, based on a highly convergent single-step assembly of the carbon skeleton. The efficient incorporation of two carbon-13 isotopes into phenethylamines was accomplished using a palladium-catalyzed double carbonylation of aryl iodides with near stoichiometric carbon monoxide.