50508-40-2

Basic information

• Product Name: Morpholine, 4-[(4-nitrophenyl)acetyl]-
• CAS NO: 50508-40-2
• Molecular Formula: C12H14N2O4
• Molecular Weight: 250.254
• Mol File: 50508-40-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Morpholine, 4-[(4-nitrophenyl)acetyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-[(4-nitrophenyl)acetyl]-(50508-40-2)
• EPA Substance Registry System: Morpholine, 4-[(4-nitrophenyl)acetyl]-(50508-40-2)

Safety Data

• Hazardous Substances Data: 50508-40-2(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 51738-10-4 2,2-dibromo-1-(4-nitrophenyl)ethene 
• 1696-20-4 4-acetylmorpholine 
• 586-78-7 para-nitrophenyl bromide 
• 1436595-58-2 tert-butyl 4-nitrophenylacetylenyl ether 
• 350-46-9 4-Fluoronitrobenzene 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 104-03-0 4-nitrobenzeneacetic acid 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 210158-20-6 4-[2-(4-nitro-phenyl)-ethyl]-morpholine 
• 262368-47-8 4-[2-(4-morpholinyl)ethyl]aniline 

Relevant articles and documents

Structure-based modification of carbonyl-diphenylpyrimidines (Car-DPPYs) as a novel focal adhesion kinase (FAK) inhibitor against various stubborn cancer cells

A family of carbonyl-substituted diphenylpyrimidine derivatives (Car-DPPYs) with strong activity against focal adhesion kinase (FAK), were described in this manuscript. Among them, compounds 7a (IC50 = 5.17 nM) and 7f (IC50 = 2.58 nM) displayed equal anti-FAK enzymatic activity to the lead compound TAE226 (6.79 nM). In particular, compound 7a also exhibited strong antiproliferative activity against several stubborn cancer cells, including AsPC-1 cells (IC50 = 0.105 μM), BxPC-3 cells (IC50 = 0.090 μM), and MCF-7/ADR cells (IC50 = 0.59 μM). Additionally, compound 7a also showed great antitumor efficacy in vivo via aAsPC-1 cancer Xenograft mouse model. The preliminary mechanism study by Western blot analysis revealed that 7a repressed FAK phosphorylation in AsPC cancer cells. Taken together, the results indicate that compound 7a may serve as a promising preclinical candidate for treatment of stubborn cancers.

The ketene-surrogate coupling: Catalytic conversion of aryl iodides into aryl ketenes through ynol ethers

tert-Butoxyacetylene is shown to undergo Sonogashira coupling with aryl iodides to yield aryl-substituted tert-butyl ynol ethers. These intermediates participate in a [1,5]-hydride shift, which results in the extrusion of isobutylene and the generation of aryl ketenes. The ketenes are trapped in situ with multiple nucleophiles or undergo electrocyclic ring closure to yield hydroxynaphthalenes and quinolines.

Palladium-catalyzed intermolecular α-arylation of zinc amide enolates under mild conditions

The intermolecular α-arylation and vinylation of amides by palladium-catalyzed coupling of aryl bromides and vinyl bromides with zinc enolates of amides is reported. Reactions of three different types of zinc enolates have been developed. The reactions of