505084-59-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-5-(trifluoromethyl)-3-pyridinecarboxylic acid is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of novel drugs. Its unique chemical properties make it a valuable component in the creation of new therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Chloro-5-(trifluoromethyl)-3-pyridinecarboxylic acid serves as an intermediate in the production of agrochemicals, helping to develop innovative compounds for agricultural applications such as pesticides and herbicides.
Used in Organic Chemistry Research and Development:
2-Chloro-5-(trifluoromethyl)-3-pyridinecarboxylic acid is utilized as a versatile building block in organic chemistry, enabling researchers to explore new reactions and syntheses. Its chemical properties make it a valuable tool for advancing the field of chemical research and development.
Used in the Production of Organic Compounds:
2-Chloro-5-(trifluoromethyl)-3-pyridinecarboxylic acid is also used in the production of various organic compounds, further expanding its applications across different industries. Its unique structure and properties allow for the creation of a wide range of organic molecules with diverse functionalities.

Upstream product

• 124-38-9 carbon dioxide 
• 505084-56-0 2-chloro-3-iodo-5-(trifluoromethyl)pyridine 
• 505084-55-9 2-chloro-4-iodo-5-(trifluoromethyl)pyridine 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 

Downstream Products

• 1360934-51-5 methyl 2-chloro-5-(trifluoromethyl)pyridine-3-carboxylate 
• 624734-22-1 2-chloro-5-(trifluoromethyl)pyridine-3-carbonitrile 
• 944900-39-4 2-amino-5-(trifluoromethyl)pyridine-3-carboxylic acid 
• 1227048-89-6 methyl 2-amino-5-(trifluoromethyl)pyridine-3-carboxylate 

Relevant academic research and scientific papers

Three chloro(trifluoromethyl)pyridines as model substrates for regioexhaustive functionalization

As a further test of the concept of regioexhaustive functionalization, 2-chloro-6-(trifluoromethyl)pyridine, 2-chloro-5-(trifluoromethyl)pyridine and 3-chloro-4-(trifluoromethyl)-pyridine were each converted into the three possible carboxylic acids 2, 4, 6, 8, 10, 12, 16, 17 and 20. This was achieved by employing several, but not all of the organometallic "tool-box methods": transformation of a more basic organometallic species into a less basic isomer by transmetalation-equilibration, site discriminating deprotonation with lithium N,N-diisopropylamide or lithium 2,2,6,6- tetramethylpiperidide, regio-divergent iodine migration and steric screening of acidic positions by a bulky trialkylsilyl group. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Recommendable routes to trifluoromethyl-substituted pyridine- and quinolinecarboxylic acids

As part of a case study, rational strategies for the preparation of all ten 2-, 3-, or 4-pyridinecarboxylic acids and all nine 2-, 3-, 4-, or 8-quinolinecarboxylic acids bearing trifluoromethyl substituents at the 2-, 3-, or 4-position were elaborated. The trifluoromethyl group, if not already present in the precursor, was introduced either by the deoxygenative fluorination of suitable carboxylic acids with sulfur tetrafluoride or by the displacement of ring-bound bromine or iodine by trifluoromethylcopper generated in situ. The carboxy function was produced by treatment of organolithium or organomagnesium intermediates, products of halogen/metal or hydrogen/ metal permutation, with carbon dioxide. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

New strategies in the synthesis of regioselectively trifluoromethyl- and trifluoromethoxy-substituted arenes as building blocks for biologically active molecules

Regioisomerically pure trifluoromethyl- and trifluoromethoxy-substituted aromatic and heteroaromatic aldehydes and carboxylic acids are valuable building blocks for the synthesis of biologically active molecules. They have been prepared by employing moder