5055-42-5

Usage

InChI:InChI=1/C22H36O2Si/c1-21-12-10-16(23)14-15(21)6-7-17-18-8-9-20(24-25(3,4)5)22(18,2)13-11-19(17)21/h14,17-20H,6-13H2,1-5H3/t17-,18-,19-,20-,21-,22-/m0/s1

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 58-22-0 testosterone 
• 18243-21-5 trimethylsilyl formate 

Relevant academic research and scientific papers

Prodrugs utilizing organosilyl derivation: An investigation of the long-term androgenic and myotrophic activities of silyl derivatives of testosterone

The long-term androgenic and myotrophic acativities of dimethylditestosteroxysilane and diphenylditestosteroxysilane were studied and compared with the activities of testosterone propionate and testosteroxytrimethylsilane. The testing was carried out in vivo, using castrated male rats, over a 50-d period. Dimethylditestosteroxysilane and diphenylditestosteroxysilane were shown to exhibit both myotrophic activity and androgenic activity. In the early stages of the study, dimethylditestosteroxysilane displayed myotrophic activity with no corresponding androgenic activity. The results presented indicate that these silyl ethers act as latentiated derivatives of testosterone.

Silylation of O-H bonds by catalytic dehydrogenative and decarboxylative coupling of alcohols with silyl formates

The silylation of O-H bonds is a useful methodology in organic synthesis and materials science. While this transformation is commonly achieved by reacting alcohols with reactive chlorosilanes or hydrosilanes, we show herein for the first time that silylformates HCO2SiR3 are efficient silylating agents for alcohols, in the presence of a ruthenium molecular catalyst.

Iron-Catalyzed Silylation of Alcohols by Transfer Hydrosilylation with Silyl Formates

An iron catalyst is shown for the first time to promote transfer hydrosilylation with silyl formates and is utilized for the silylation of alcohols. Attractive features of this protocol include the use of an earth-abundant transition-metal catalyst, mild reaction conditions, and the release of gases as the only byproducts (H 2 and CO 2).